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Chemical compound
Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor. Marimastat
Marimastat
Enzyme
called "hydroxamate-based MMP inhibitors“. An example can be seen in Marimastat, a first generation inhibitor, which has a similar backbone and sidechain
Metalloprotease_inhibitor
as anticancer drugs. Examples include: Batimastat Cipemastat Ilomastat Marimastat Prinomastat Rebimastat Tanomastat Metalloproteinase inhibitors are found
Matrix metalloproteinase inhibitor
Matrix_metalloproteinase_inhibitor
British based Biotechnology company
$2.5 billion, largely on the basis of its two main development drugs: marimastat (a novel matrix metalloprotease inhibitor for cancer treatment) and lexipafant
British_Biotech
Family of zinc-dependent metalloendopeptidases
suspected to be involved in (see above). However, most of these, such as marimastat (BB-2516), a broad-spectrum MMP inhibitor, and cipemastat (Ro 32-3555)
Matrix_metalloproteinase
Chemical compound
administered orally (as opposed to the newer and chemically similar MMPI marimastat), and injection into the peritoneum caused peritonitis. It is well-known
Batimastat
Protein-coding gene in humans
generally safe with minimal adverse side effects. Additionally, trials with marimastat did show a slight increase in survival of patients with gastric or pancreatic
MMP2
Enzyme
effects including inhibition of MMP-1) F81-1144b Hydrangenol Ilomastat Marimastat Prinomastat (weak inhibition of MMP-1 compared to MMP-2, 3, 9, 13, and
Interstitial_collagenase
inhibitors, DPP-4 inhibitors, and exogenous MMP inhibitors like batimastat and marimastat. Various enkephalinase inhibitors, such as ketalorphan, spinorphin, and
Exopeptidase_inhibitor
lymphoma – Mammary – Mammogram – Mammography – Mammotome – Mantle field – Marimastat – Mast cell – Mastectomy – Mastocytoma – Matrix metalloproteinase – MDL
Index_of_oncology_articles
Chemical compound
with these compounds have to date produced equivocal results. Batimastat Marimastat Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials
Tanomastat
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