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Chemical compound
LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases
LY294002
Class of enzymes
and LY294002, although certain members of the class II PI3K family show decreased sensitivity. Wortmannin shows better efficiency than LY294002 on the
Phosphoinositide_3-kinase
Chemical compound
concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in
Wortmannin
Human protein-coding gene
3-kinases are inhibited by the drugs wortmannin and LY294002 but wortmannin shows better efficiency than LY294002 on the hotspot mutation positions. Alpelisib
P110α
Biological protein kinase C inhibitor
structures reveal the mechanism of serine/threonine kinase inhibition by LY294002". J Biol Chem. 280 (14): 13728–13734. doi:10.1074/jbc.M413155200. PMID 15657054
BIM-1
Protein-coding gene in the species Homo sapiens
WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE 1e7v: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN
PIK3CG
Small molecules that inhibit the Hedgehog signaling pathway
Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. OncoTargets and therapy. 2015;8:877. Han JB, Sang F, Chang JJ, Hua YQ
Hedgehog_pathway_inhibitor
Neuropeptide that regulates arousal, wakefulness, and appetite
mostly conferred via the PI3K pathway because this pathway inhibitor (LY294002) completely blocks OXA effects in adipocytes. The link between OXA and
Orexin
Medical drug glass
SF1126 is a peptidic prodrug targeting integrin receptors that converts to LY294002, one of the most widely studied dual PI3K/mTOR inhibitors. A phase II trial
Phosphoinositide 3-kinase inhibitor
Phosphoinositide_3-kinase_inhibitor
Drug class
differentiation of oligodendrocyte progenitor cells. RVX-208 ABBV-744 LY294002 (some PI3K and BRD2, BRD3, and BRD4) AZD5153 MT-1 MS645 Zavabresib has
BET_inhibitor
Protein domain
"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine". Molecular Cell. 6 (4): 909–19
C2_domain
Protein-coding gene in the species Homo sapiens
Pim-1 bound to staurosporine 1yi3: Crystal Structure of Pim-1 bound to LY294002 1yi4: Structure of Pim-1 bound to adenosine 1ywv: Crystal Structures of
PIM1
"Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine". Molecular Cell. 6 (4): 909–919
Roger_L._Williams
Animal gene
resistance to apoptosis, whereas treatment of cells with the PI3K inhibitor LY294002 decreased CUX1 expression and increased apoptosis. Whether the discrepancies
CUX1
Protein found in humans
important for efficient recruitment of Dock7 since the PI3K inhibitor LY294002 was shown to block Dock7-dependent functions in neurons. This observation
Dedicator of cytokinesis protein 7
Dedicator_of_cytokinesis_protein_7
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