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Composite structure formed by phospholipids
A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility
Liposome
Structures containing lipids
Cationic liposomes are spherical structures that contain positively charged lipids. Cationic liposomes can vary in size between 40 nm and 500 nm, and
Cationic_liposome
Ligand-targeted liposomes for use in medical applications
A ligand-targeted liposome (LTL) is a nanocarrier with specific ligands attached to its surface to enhance localization for targeted drug delivery. The
Ligand-targeted_liposome
Route of drug administration
using chemical and physical agents. For chemical agents, carriers like liposomes and nanotechnologies are used to enhance the absorption of topical drugs
Topical_drug_delivery
Lab equipment
A liposome extruder is a device that prepares cell membranes, exosomes and also generates nanoscale liposome formulations. The liposome extruder employs
Liposome_extruder
Academic journal
The Journal of Liposome Research is a peer-reviewed academic journal that publishes original research on the topics of liposomes and related systems,
Journal_of_Liposome_Research
Chemotherapy medication
Organization's List of Essential Medicines. Versions that are pegylated and in liposomes are also available; however, they are more expensive. Doxorubicin was
Doxorubicin
Chemical compound
to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro. Gene therapy vectors (such as viruses) can be
Polyethylene_glycol
A unilamellar liposome is a spherical liposome, a vesicle, bounded by a single bilayer of an amphiphilic lipid or a mixture of such lipids, containing
Unilamellar_liposome
Antibiotic medication
antibiotic for empiric therapy for people with neutropenia and fever. A liposome inhalation suspension is also available and approved to treat Mycobacterium
Amikacin
Technologies for targeted drug delivery
chosen according to the target environment or desired effect. For example, liposome-based nanoparticles can be biologically degraded after delivery, thus minimizing
Nanoparticle_drug_delivery
Process of introducing nucleic acids into eukaryotic cells
squeezing, or by mixing a cationic lipid with the material to produce liposomes that fuse with the cell membrane and deposit their cargo inside. Transfection
Transfection
Cancer treatment
hydrophilic and hydrophobic drugs, liposomes are a popular choice for pH-responsive tumor-targeted drug delivery. The liposome can be modified to facilitate
PH-responsive tumor-targeted drug delivery
PH-responsive_tumor-targeted_drug_delivery
Any small, fluid-filled, spherical organelle enclosed by a membrane
called liposomes (not to be confused with lysosomes). If there is only one phospholipid bilayer, the vesicles are called unilamellar liposomes; otherwise
Vesicle (biology and chemistry)
Vesicle_(biology_and_chemistry)
Chemical compound
kind of phospholipid. Along with other lipids, it can be used to prepare liposomes. Liposomal drug delivery system from laboratory to clinic, N. A. Kshirsagar
Dimyristoylphosphatidylcholine
Dimyristoylphosphatidylcholine
Intracranial drug administration using nanotechnology
of nanoparticle involves use of liposomes as drug molecule carriers. The diagram on the left shows a standard liposome. It has a phospholipid bilayer separating
Nanoparticles for drug delivery to the brain
Nanoparticles_for_drug_delivery_to_the_brain
Transfection reagent
cultures by lipofection. Lipofectamine contains lipid subunits that can form liposomes in an aqueous environment, which entrap the transfection payload, e.g
Lipofectamine
Cancer medication
February 2024, the US Food and Drug Administration (FDA) approved irinotecan liposome, in combination with oxaliplatin, fluorouracil, and leucovorin, for the
Irinotecan
Greek biochemist and academic (1934–2026)
January 2026) was a Greek-born British biochemist who pioneered the use of liposomes in drug targeting and vaccine development. His work laid the foundation
Gregory_Gregoriadis
there are still no standardized rule for nanoparticles specifically. Liposomes are sphere-shaped vesicular structures self-assembled in a solvent composed
Nanotechnology_in_cosmetics
Lipid that is soluble in nonpolar solvents with their respective range
allows them to form structures such as vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment. Biological lipids originate entirely
Lipid
used nanocarriers include micelles, polymers, carbon-based materials, liposomes and other substances. Nanocarriers are currently being studied for their
Nanocarrier
attaching nanoparticles and liposomes to the microbubble surface, (3) enveloping the microbubble within a larger liposome, and (4) electrostatically bonding
Microbubble
Biological membrane structure
lipid bilayers has been the use of liposomes for drug delivery, especially for cancer treatment. (Note- the term "liposome" is in essence synonymous with
Lipid_bilayer
Layer packing of chain molecules with polar and nonpolar ends in a bulk liquid
membranes, and structure of lipid bilayer in unilamellar liposomes. In multilamellar liposomes, many such lipid bilayer sheets are layered concentrically
Lamellar_phase
U.S. healthcare company
Although larger liposomes can be manufactured, the most useful size range for drug carrier applications is 80-100 nanometers. NanoLiposomes of this size
Cerenome
Antifungal and antiparasitaric chemical compound
the liposome is disrupted when it binds to the fungal cell wall, but is not affected by the mammalian cell membrane, so the association with liposomes decreases
Amphotericin_B
Drug delivery to the bladder
are through developing formulations using mucoadhesives, nanoparticles, liposomes, polymeric hydrogel, expandable delivery devices, and electromotive drug
Intravesical_drug_delivery
American chemical engineer
mentorship of Robert K. Prud'homme, where she designed and tested novel liposome structures for potential use in drug delivery platforms. She worked on
Debra_Auguste
Pharmaceutical compound
penetration of Finasteride loaded DMSO-liposomes for the treatment of androgenic alopecia: comparison with conventional liposomes". Drug Development and Industrial
Minoxidil/finasteride
Plant extract
inside cholestrol-based liposomes. Army Liposome Formulation Q (ALFQ), MPL and QS-21 sealed inside cholesterol-based liposomes produced by the US Army
QS-21
Austrian-born American physician/scientist, editor and essayist
was its book review editor. In 1965, he was one of the discoverers of liposomes and is credited with coining that term. Weissmann was born in Vienna,
Gerald_Weissmann
Method of delivering medication
contrast agent in magnetic resonance imaging. Thus, by grafting these liposomes with a desired drug to deliver to a region of the body, magnetic positioning
Targeted_drug_delivery
Component of vaccines
molecules, so called pathogen-associated molecular patterns, which include liposomes, lipopolysaccharide, molecular cages for antigens, components of bacterial
Immunologic_adjuvant
Inert medium used in drug-delivery systems
disadvantages. Some of the more popular types of drug carriers include liposomes, polymeric micelles, microspheres, and nanoparticles. Different methods
Drug_carrier
Chemical compound
synthesis and DNA replication. OSI-7904L is a liposome-encapsulated formulation of OSI-7904. Liposome encapsulation improves the efficacy and increases
OSI-7904
Topics referred to by the same term
2021 song by Jack Harlow and Pooh Shiesty A small unilamellar liposome/vesicle, a liposome with a single lipid bilayer Standardized uptake value, a term
SUV_(disambiguation)
therapeutic methods such as drug-loaded microbubbles, nanoparticles, exosomes, liposomes, and genes for improved efficacy. Currently, SDT does not have any clinical
Sonodynamic_therapy
French biopharmaceutical company
In February 2024, Ipsen received FDA approval for Onivyde (irinotecan liposome injection), which is used in combination with oxaliplatin, fluorouracil
Ipsen
Class of lipids
bio-availability, reduced toxicity and increased permeability across membranes. Liposomes are often composed of phosphatidylcholine-enriched phospholipids and may
Phospholipid
Generic term for amphiphilic substances of plant and animal origin
excellent emulsifier. In aqueous solution, its phospholipids can form either liposomes, bilayer sheets, micelles, or lamellar structures, depending on hydration
Lecithin
Biological membrane that separates the interior of a cell from its outside environment
compounds perform the same function as cholesterol. Lipid vesicles or liposomes are approximately spherical pockets that are enclosed by a lipid bilayer
Cell_membrane
Path by which a drug, fluid, poison, or other substance is taken into the body
application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas". Journal of Neurology, Neurosurgery
Route_of_administration
Chemical compound used in cancer therapy
(formerly known as Stimuvax, L-BLP25, BLP25 liposomal vaccine, or BLP25 liposome vaccine). The investigational therapeutic cancer vaccine is designed to
Tecemotide
Gene that inhibits tumorigenic phenotype
introduction and are divided into two categories which are naked plasmid or liposome-coated plasmids. The naked plasmid strategy has garnered interest because
Tumor_suppressor_gene
Non-ionic surfactant-based vesicle
Structurally, niosomes are similar to liposomes as both consist of a lipid bilayer. However, niosomes are more stable than liposomes during formation processes and
Niosome
Chemical compound; chemotherapy medication
these carbons is responsible for vincristine's anticancer activity. The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug
Vincristine
In cellular biology, thin layer, membrane, or plate of tissue
lamellar phase. Thus, each bilayer of multilamellar liposomes and wall of a unilamellar liposome is also referred to as a lamella. Middle lamella Thylakoid
Lamella_(cell_biology)
Heterogeneous mixture of solid particles dispersed in a medium
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Suspension_(chemistry)
British biophysicist (1921–2010)
studied blood clotting mechanisms but became well known for his research on liposomes and his invention of clinically useful artificial lung surfactants. Bangham
Alec_Bangham
Drug delivery form in which the ingredients are solidified for later consumption
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Tablet_(pharmacy)
Medical injection into a muscle
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Intramuscular_injection
Method of targeted drug delivery
Immunoliposome therapy is a targeted drug delivery method that involves the use of liposomes (artificial lipid bilayer vesicles) coupled with monoclonal antibodies
Immunoliposome_therapy
Herbal liquid
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Tincture
Chemical entity that reversibly binds ions
electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). Structurally, an ionophore contains a hydrophilic center and a hydrophobic
Ionophore
Dry, bulk solid composed of fine, free-flowing particles
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Powder
American physician and biochemist
landmark experiment that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production
Robert_W._Malone
American synthetic biologist
world hypothesis of the origin of life. She has worked on constructing liposome bioreactor synthetic cells. She is a founder and steering group member
Kate_Adamala
American biochemist and immunologist
postdoctoral research at the University of Virginia, where he studied liposomes—lipid-based structures investigated for their potential use in drug delivery
Philip_Felgner
area of gene therapy and targeted drug delivery. He has pioneered the liposome non-viral vector and has designed and manufactured the cationic lipid vector
Leaf_Huang
Medical technique
Lentacker, I.; Averkiou, M.; Bouakaz, A. (January 2013). "Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug
Focused ultrasound for intracranial drug delivery
Focused_ultrasound_for_intracranial_drug_delivery
Type of artificial cell
and replicate." The growth medium also contains nucleotide bases and liposomes which contain transfer RNA derived from E. coli, sugars, lipids, and enzymes
SpudCell
Pharmaceutical drug
applied encapsulated into liposomes (L-MTP-PE). Being a phospholipid, it accumulates in the lipid bilayer of the liposomes in the infusion. One synthesis
Mifamurtide
Highly viscous liquid exhibiting a kind of semi-solid behavior
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Gel
Medication applied to body surfaces
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Topical_medication
Liposome
Nanomaterials_and_cancer
Needle-free medical injection syringe
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Jet_injector
Form of administering nutrition
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Nutrient_enema
a liposome, causes disturbances to the packing of the lipids on the side of the bilayer that has the larger surface area (the outside of a liposome for
Amphipathic lipid packing sensor motifs
Amphipathic_lipid_packing_sensor_motifs
Species of archaeon
Archaea is unique in composition. Archaea lipids are a promising source of liposomes with stable temperature and pH and tightness against the leakage of solute
Sulfolobus_solfataricus
similar to liposomes, which are vesicles formed from naturally occurring lipids. While having many of the properties of natural liposomes, polymersomes
Polymersome
by inhibiting their dissociation from the Mydd88 complex. Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was
IRAK3
Chemical compound
microinjection or scrape loading. It can be incorporated into liposomes, and allows for the tracking of liposomes as they pass through the body. In addition, carboxyfluorescein
6-Carboxyfluorescein
self-organize, and any molecules caught inside will become the contents of a liposome, and would be concentrated enough to allow chemical reactions to transform
Primordial_sandwich
Chemical reaction
hepatitis B (Schering-Plough/Enzon, 2000) Doxorubicin HCl liposome (Doxil/Caelyx) – PEGylated liposome containing doxorubicin for the treatment of cancer (Alza
PEGylation
Canadian researcher
co-founded (Inex Pharmaceuticals Corp, Protiva Biotherapeutics, Canadian Liposome Company, Acuitas Therapeutics). "Pieter R. Cullis, PhD". CMHF. 12 May 1946
Pieter_Cullis
Class of antibiotics
stabilised liposomes, consisting of unilamellar liposomes coated with hydrophilic polymer polyethylene glycol (PEG) that is covalently linked to liposome phospholipids
Anthracycline
Medical injection into the dermis
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Intradermal_injection
Chemical compound
collapse during breathing. It also plays an important role in the study of liposomes and human bilayers. Lung surfactant (LS) is a surface-active material
Dipalmitoylphosphatidylcholine
Dipalmitoylphosphatidylcholine
Russian-American chemist
Nanomedicine at Northeastern University. Torchillin researches topics like liposomes, lipid-core micelles, biomedical polymers, drug delivery and targeting
Vladimir_Torchilin
constructs is known as "koding" and the resultant "koded" cells, viruses and liposomes are respectively known as kodecytes, and kodevirions. All living surfaces
Function-spacer-lipid Kode construct
Function-spacer-lipid_Kode_construct
Radiation scattering technique
types including interpolyelectrolyte complexes, micelles, microgels, liposomes, polymersomes, metals, cement, oil, polymers, plastics, proteins, foods
Small-angle_X-ray_scattering
Advanced controlled release oral drug delivery system
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Osmotic-controlled release oral delivery system
Osmotic-controlled_release_oral_delivery_system
American businessman
Intellect Neurosciences. He was also instrumental in the turnaround of Liposome Technology Inc. and Biotech General Corporation. In 1990, Blech founded
David_Blech
Szoka, Francis C. (1986). "Fusion of phosphatidylethanolamine-containing liposomes and mechanism of L.alpha.-HII phase transition". Biochemistry. 25 (14):
Lipid_bilayer_fusion
Oncologist (b. 1958)
experiment using 99mTc labelled polyphase liposome and application of the radio-imaging with 99mTc-polyphase liposome". Journal of Shenyan College of Pharmacy
Yu_Baofa
Kester, this patent describes the process of loading Ceramide nano-scale liposomes with anti-cancer compounds and create a combination of therapies that
Keystone_Nano
Hungarian immunologist
nanomedicines, particularly liposomes and lipid nanoparticles. He was among the early contributors to the development of liposome-encapsulated hemoglobin
Janos_Szebeni
Domain of microorganisms
Santhosh PB, Genova J (10 January 2023). "Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications"
Bacteria
Subfield of condensed matter physics
The self-assembly of individual phospholipids into colloids (Liposome and Micelle) or a membrane (bilayer sheet).
Soft_matter
Weed control herbicide
gondii and cryptosporidiosis is effective but limited due to solubility. Liposome-administered trifluralin has been used to treat leishmania in dogs successfully
Trifluralin
Vesicles found outside cells
diameter from near the size of the smallest physically possible unilamellar liposome (around 20–30 nanometers) to as large as 10 microns or more, although the
Extracellular_vesicle
Novel drug delivery system
addition, polymeric nanoparticles, self-emulsifying delivery systems, liposomes, microemulsions, micellar solutions and recently, solid lipid nanoparticles
Lipid-based_nanoparticle
Range of spectroscopic analysis
(19 September 1994). "Absorption flattening in the optical spectra of liposome-entrapped substances". FEBS Letters. 352 (1): 37–40. Bibcode:1994FEBSL
Ultraviolet–visible spectroscopy
Ultraviolet–visible_spectroscopy
Optical biosensing technology
"Application of Bio-Layer Interferometry for the analysis of protein/liposome interactions". Journal of Pharmaceutical and Biomedical Analysis. 72: 150–154
Bio-layer_interferometry
Liquid applied directly to the eye
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Eye_drop
Drug delivery device
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Nebulizer
Branch of biology that studies biological systems at the molecular level
as calcium phosphate transfection, electroporation, microinjection and liposome transfection. The plasmid may be integrated into the genome, resulting
Molecular_biology
Drug delivery via inhalation
controlled release. Liposomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsions are examples. Liposomes are made up of
Nose-to-brain drug delivery mechanism
Nose-to-brain_drug_delivery_mechanism
Indian immunologist and nanotechnologist
non-phosphatidylcholine liposome as vehicle for delivery of antigens in prophylactic treatment of experimental leishmaniasis. Further, the liposome/niosome based
Owais_Mohammad
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