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Concept in drug discovery
A lead compound (/ˈliːd/, i.e., a "leading" compound; not to be confused with various compounds of the element lead) in drug discovery is a chemical compound
Lead_compound
Type of compound
Compounds of lead exist with lead in two main oxidation states: +2 and +4. The former is more common. Inorganic lead(IV) compounds are typically strong
Lead_compounds
Chemical element with atomic number 82 (Pb)
organolead compounds. Like the lighter members of the group, lead can bond with itself, forming chains and polyhedral structures. Since lead is easily
Lead
Pharmaceutical discovery procedure
a lead compound series has been established with sufficient target potency and selectivity and favourable drug-like properties, one or two compounds will
Drug_discovery
Chemical element with atomic number 51 (Sb)
mainly in the form of the sulfide mineral stibnite (Sb2S3). Antimony compounds have been known since ancient history and were powdered for use as medicine
Antimony
Chemical compound
Lead(II,IV) oxide, also called red lead, lead tetroxide, or minium, is the inorganic compound with the formula Pb3O4. A bright red or orange solid, it
Lead(II,IV)_oxide
Organolead compound
Tetraethyllead (commonly styled tetraethyl lead), abbreviated TEL, is an organolead compound with the formula Pb(C2H5)4. It was widely used as a fuel
Tetraethyllead
Chemical compound
Lead(II) acetate, also known as lead(II) ethanoate and formerly known as sugar of lead, is a white crystalline chemical compound with a slightly sweet
Lead(II)_acetate
Variety of glass in which lead replaces the calcium content
Lead could be added directly to a ceramic body in the form of a lead compound in suspension, either from galena (PbS), red lead (Pb3O4), white lead (2PbCO3·Pb(OH)2)
Lead_glass
Poisoning caused by lead in the body
the use of organic lead compounds as gasoline additives. These compounds are still used in industrial settings. Organic lead compounds, which cross the
Lead_poisoning
Compound with a similar structure to another
initial lead compound are created and tested as part of a structure–activity relationship study or a database is screened for structural analogs of a lead compound
Structural_analog
Stage of drug discovery
identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization
Hit_to_lead
Chemical compound
Lead(II) nitrate is an inorganic compound with the chemical formula Pb(NO3)2. It commonly occurs as a colourless crystal or white powder and, unlike most
Lead(II)_nitrate
Chemical compound
and hydroxide. White lead compounds known as lead soap were used as additive for lubricants for bearings and in machine shops. Lead soap was also used as
White_lead
Chemical compound
Lead(II) carbonate is the chemical compound with the chemical formula PbCO3. It is a white, toxic solid. It occurs naturally as the mineral cerussite
Lead_carbonate
Chemical compound
Lead(II) oxide, also called lead monoxide, is the inorganic compound with the molecular formula PbO. It is insoluble in water. It occurs in two polymorphs:
Lead(II)_oxide
Chemical compound
Lead(II) sulfide (also spelled sulphide) is an inorganic compound with the formula PbS. It occurs naturally as galena, the principal ore and the most
Lead(II)_sulfide
Chemical compound
Lead(IV) oxide, commonly known as lead dioxide, is an inorganic compound with the chemical formula PbO2. It is an oxide where lead is in an oxidation state
Lead_dioxide
organolead compounds, which are organometallic compounds containing a chemical bond between carbon and lead. The first organolead compound was hexaethyldilead
Organolead_chemistry
Index of chemical compounds with the same name
Lead oxides are a group of inorganic compounds with formulas including lead (Pb) and oxygen (O). Common lead oxides include: Lead(II) oxide, PbO, litharge
Lead_oxide
Liquid fuel derived from petroleum
formulated as a fuel for engines, gasoline is chemically composed of organic compounds derived from the fractional distillation of petroleum and later chemically
Gasoline
American pharmaceutical company
acquisition of Soliton. In June, Abbvie acquired TeneoOne and its lead compound TNB-383B. The compound is a BCMA-targeting immunotherapeutic for relapsed or refractory
AbbVie
Rechargeable battery type often used in motor vehicles
900,000 short tons) of lead. Some lead compounds are extremely toxic. Long-term exposure to even tiny amounts of these compounds can cause brain and kidney
Lead–acid_battery
Chemical groups which can be substituted to enhance therapeutic activity of drugs
bioavailability, or modify the activity of the lead compound, and may alter the metabolism of the lead. Classical bioisosterism was originally formulated
Bioisostere
Topics referred to by the same term
gas Lead (sea ice), a temporary stretch of open water in pack ice Lead compound, a chemical compound in drug discovery (not necessarily with lead the
Lead_(disambiguation)
Chemical compound
Lead(II) chloride (PbCl2) is an inorganic compound which is a white solid under ambient conditions. It is poorly soluble in water. Lead(II) chloride is
Lead(II)_chloride
Yellow pigment used in oil painting
Lead-tin yellow is a yellow pigment, of historical importance in oil painting, sometimes called the "Yellow of the Old Masters" because of the frequency
Lead-tin_yellow
Lead oxychlorides are halide compounds of lead with the general formula PbClO(H). Lead oxychlorides are found naturally in the minerals hereroite as Pb32O212Cl10
Lead_oxychloride
Chemical compound
Basic lead acetate, also known as subacetate of lead, is the inorganic compound with the formula Pb3(OH)4(O2CCH3)2. A white solid, it is one of several
Basic_lead_acetate
Chemical compound
mercury fulminate or lead azide. It is stable in storage, even at elevated temperatures. As with other lead-containing compounds, lead styphnate is toxic
Lead_styphnate
initial lead compound in this series. Further development of that lead compound led to the discovery of compound A in figure 7 — a compound that possesses
CCR5_receptor_antagonist
Chemical compound
Lead stearate is a metal-organic compound, a salt of lead and stearic acid with the chemical formula C 36H 70PbO 4. The compound is classified as a metallic
Lead_stearate
Compound of Lead
Lead citrate is a compound of lead and citrate that is primarily used as an enhancer for heavy metal staining in electron microscopy. This salt binds to
Lead_citrate
lead-based paint in the United Kingdom were banned from sale to the general public in 1992, except for specialist uses. Prior to this, lead compounds
Lead-based paint in the United Kingdom
Lead-based_paint_in_the_United_Kingdom
Chemical compound
Lead(II) azide Pb(N3)2 is an inorganic compound. More so than other azides, it is explosive. It is used in detonators to initiate secondary explosives
Lead(II)_azide
Process of bringing a new pharmaceutical drug to the market
process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes
Drug_development
Chemical compound
Lead fluorochloride or lead fluoride chloride is an inorganic compound of lead, fluorine, and chlorine with the chemical formula PbFCl. The compound contains
Lead_fluorochloride
Chemical compound
Lead(II) hydroxide is an inorganic compound with the formula Pb(OH)2. The material has not been isolated but its existence has been inferred as an ill-defined
Lead(II)_hydroxide
Lead apatite is a generic name for apatite-structure materials that contain lead as the divalent cation. A Copper-doped lead-apatite has been proposed
Lead_apatite
Paint containing lead compounds as pigments
Lead paint or lead-based paint is paint containing lead. As pigment, lead(II) chromate (PbCrO 4, "chrome yellow"), lead(II,IV) oxide (Pb 3O 4, "red lead")
Lead_paint
Chemical compound
inhalation but also ingestion and dermal contact. Lead compounds are also teratogens. "Lead compounds: Lead Tetrachloride". WebElements.com. Retrieved 10
Lead(IV)_chloride
Chemical compound
Lead zirconate titanate, also called lead zirconium titanate and commonly abbreviated as PZT, is an inorganic compound with the chemical formula Pb[ZrxTi1−x]O3
Lead_zirconate_titanate
Chemical drug alteration process
modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug. This could mean
Molecular_modification
Substance composed of multiple chemically bonded elements
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element
Chemical_compound
Principal curcuminoid of turmeric
bioavailable. It is unlikely to produce useful leads for drug development as a lead compound. Curcumin was named in 1815 when Henri Auguste Vogel and Pierre Joseph
Curcumin
Index of chemical compounds with the same name
Lead fluoride may refer to: Lead(II) fluoride (lead difluoride, plumbous fluoride, PbF2), a white powder Lead(IV) fluoride (lead tetrafluoride, tetrafluoroplumbane
Lead_fluoride
DNA-based experimental drug
aptamer, a synthetic DNA compound designed to bind other chemicals. BC-007 is in early-stage clinical trials as a lead compound intended for the potential
BC-007
Compounds containing at least one radium atom
radium's alpha decay. Insoluble radium compounds coprecipitate with all barium, most strontium, and most lead compounds. Radium oxide (RaO) has not been characterized
Radium_compounds
Chemical element with atomic number 24 (Cr)
mines in the Ural Mountains which he named Siberian red lead. Though misidentified as a lead compound with selenium and iron components, the mineral was in
Chromium
Organometallic compound (Pb(C2H3O2)4)
Lead(IV) acetate or lead tetraacetate is an metalorganic compound with chemical formula (CH3CO2)4Pb, often abbreviated as Pb(OAc)4, where Ac is acetyl
Lead(IV)_acetate
Chemical compound
Medicine (CSEM): Lead Toxicity Archived 2024-02-27 at the Wayback Machine ToxFAQs: Lead National Pollutant Inventory - Lead and Lead Compounds Fact Sheet
Lead(II)_sulfate
Opioid analgesic
on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active. U-47700 became the lead compound of selective
U-47700
Chemical compound
Lead fluorobromide or lead fluoride bromide is an inorganic compound of lead, fluorine, and bromine with the chemical formula PbFBr. The compound is a
Lead_fluorobromide
Chemical compound
Lead picrate is an organic picrate salt. It is a sensitive and highly explosive compound that is typically found as a hydrate. Dry lead picrate is extremely
Lead_picrate
Compound containing a plumbide anion
intermetallic compound that contains lead, or a Zintl phase compound with lead as the anion. Plumbides can be formed when lead forms a Zintl phase compound with
Plumbide
Chemical compound
atom clusters. This compound is stable in the air. Lead heptaphosphide can be produced by the reaction of red phosphorus and lead: 7 P4 + 4 Pb → 4 PbP7
Lead_heptaphosphide
Chemical compound
Lead tetrafluoride is a compound of lead and fluorine. The yellow solid (melting point 600 °C) is the only room-temperature stable tetrahalide of lead
Lead_tetrafluoride
Scientific branch of chemistry
needed] The final synthetic chemistry stages involve the production of a lead compound in suitable quantity and quality to allow large scale animal testing
Medicinal_chemistry
Chemical compound
Lead magnesium niobate is a relaxor ferroelectric. It has been used to make piezoelectric microcantilever sensors. Bokov, A. A.; Ye, Z. -G. (2006). "Recent
Lead_magnesium_niobate
Chemical compound
Lead(II) phosphate is an ionic compound with chemical formula Pb3(PO4)2. Lead(II) phosphate is a long-lived electronically neutral reagent chemical. Despite
Lead(II)_phosphate
Chemical compound
that its p-type performance could equal or exceed that of the sister compound, lead telluride. Several groups have since reported thermoelectric figures
Lead_selenide
Collection of chemicals
effectiveness in their management. Compound management Druglikeness Lead compound Scientific collection Chemoproteomics Ian Yates. Compound Management comes of age
Chemical_library
Chemical compound
Lead(II) bromide is the inorganic compound with the formula PbBr2. It is a white powder. It is produced in the burning of typical leaded gasolines. It
Lead(II)_bromide
Cosmetic product
played a significant role in the pigment trade. The white lead present in ceruse was the same compound used in cosmetic products, in medications, and by artists
Venetian_ceruse
Chemical compound
Lead(II) titanate is an inorganic compound with the chemical formula PbTiO3. It is the lead salt of titanic acid. Lead(II) titanate is a yellow powder
Lead_titanate
Chemical compound
inorganic chemical compound with the chemical formula PbH4. It is a colorless gas. It is a metal hydride and group 14 hydride composed of lead and hydrogen
Plumbane
Chemical compound
Lead(IV) sulfide is a chemical compound with the formula PbS2. This material is generated by the reaction of the more common lead(II) sulfide, PbS, with
Lead(IV)_sulfide
Index of chemical compounds with the same name
Lead sulfide refers to two compounds containing lead and sulfur: Lead(II) sulfide, PbS, containing lead in the +2 oxidation state, naturally occurring
Lead_sulfide
Chemical compound
transporter reuptake inhibitor used as a lead compound to find a DRI transporter site antagonist (i.e. a compound that fills the ligand binding site without
4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone
4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl_4-methylphenyl_ketone
Chemical compound
structure to penicillin N, was never commercialized. Cephalosporin C was a lead compound for the discovery and production of many other cephalosporins. Cephalosporins
Cephalosporin_C
Chemical compounds with at least one bismuth atom
Bismuth forms mainly trivalent and a few pentavalent compounds. Many of its chemical properties are similar to those of arsenic and antimony, although
Bismuth_compounds
Chemical compound
Lead polonide is the polonide of lead, with the chemical formula of PbPo. It occurs naturally, as lead is produced in the alpha decay of polonium. Lead
Lead_polonide
American pharmaceutical company
2021, the business announced it would acquire Forendo Pharma and its lead compound, a potentially first-in-class oral 17β-hydroxysteroid dehydrogenase
Organon_&_Co.
Measure of a ligand's binding energy per atom
in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological
Ligand_efficiency
Chemical compound
Lead(II) iodide (or lead iodide) is a chemical compound with the formula PbI 2. At room temperature, it is a bright yellow odorless crystalline solid
Lead(II)_iodide
Canadian biochemist
treatment. Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August
Tak_Wah_Mak
Chemical element with atomic number 25 (Mn)
Methylcyclopentadienyl manganese tricarbonyl (MMT) is an additive developed to replace lead compounds for gasolines to improve the octane rating. MMT is used only in a few
Manganese
Chemical compound
Lead(II) fluoride is the inorganic compound with the formula PbF2. It is a white solid. The compound is polymorphic, at ambient temperatures it exists
Lead(II)_fluoride
Chemical compound
antibacterial properties and has served as a lead compound for the development of more potent antibactierial compounds. Merck Index (11th ed.). p. 701. 4359
Glucovanillin
Chemical compound
Lead telluride is a compound of lead and tellurium (PbTe). It crystallizes in the NaCl crystal structure with Pb atoms occupying the cation and Te forming
Lead_telluride
Type of firework
This effect became controversial because of the toxic compounds once used, particularly lead tetroxide Pb3O4. Bismuth trioxide or bismuth subcarbonate
Dragon's_egg
Common synthetic polymer
"no concern" for consumer exposure including exposure to children. Lead compounds had previously been widely added to PVC to improve workability and stability
Polyvinyl_chloride
Chemical compound or substance produced by a living organism, found in nature
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include
Natural_product
Chemical element with atomic number 50 (Sn)
(Sn(C4H9)3H). These compounds release transient tributyl tin radicals, which are rare examples of compounds of tin(III). Organotin compounds, sometimes called
Tin
Chemical element with atomic number 20 (Ca)
most abundant metal, after iron and aluminium. The most common calcium compound on Earth is calcium carbonate, found in limestone and the fossils of early
Calcium
Hypothetical chemical compound of carbon and lead
Lead carbide is a hypothetical chemical compound of carbon and lead. Lead and elemental carbon do not normally combine, even at very high temperatures
Lead_carbide
Toxic effect of metal ions on living cells
and inhibits the growth of bacteria. Lead arsenate is used in insecticides and herbicides. Organic lead compounds have been used as biocides, including
Oligodynamic_effect
Chemical element with atomic number 49 (In)
sphalerite and other zinc sulfide ores. Indium has no biological role and its compounds are toxic when inhaled or injected into the bloodstream, although they
Indium
Blue dye also used as a medication
1933 by Matilda Brooks. Methylene blue was the original prototype or lead compound for the design of many antimalarials including chloroquine, antihistamines
Methylene_blue
Chemical compound
polymerization. Ebselen has been entered into clinical trials as a lead compound intended for the potential treatment of various diseases. Its most advanced
Ebselen
Sense of chemicals on the tongue
glycyrrhizin, artificial sweeteners (organic compounds with a variety of structures), and lead compounds such as lead acetate.[citation needed] It is often connected
Taste
Chemical compound
as a lead compound. Development of andarine for all indications has been discontinued, in favor of the structurally related and improved compound enobosarm
Andarine
Chemical compound containing a noble gas element
form helides, and claimed to succeed in forming a compound of helium with lead-214, and a compound of helium with bismuth-214. See for an extensive listing
Noble_gas_compound
Chemical compound
Medicine - Lead Toxicity Archived 2016-02-04 at the Wayback Machine National Pollutant Inventory - Lead and Lead Compounds Fact Sheet Lead arsenate history
Lead_hydrogen_arsenate
Chemical compound
Lead(II) laurate is a metal-organic compound with the chemical formula Pb(O2C(CH2)10CH3)2. It is classified as a metallic soap, i.e. a metal derivative
Lead(II)_laurate
Periodic table group
and tetraiodide of lead are unstable. Lead forms four oxides, a sulfide, a selenide, and a telluride. There are no known compounds of flerovium. The boiling
Carbon_group
Swiss biopharmaceutical company
for serious diseases with few or no existing treatment options. Its lead compound, RLF-100, is a synthetic form of a natural peptide that protects the
Relief_Therapeutics
Method used in drug discovery
Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug
Fragment-based_lead_discovery
Class of chemical compounds
Methylammonium lead halides (MALHs) are solid compounds with perovskite structure and a chemical formula of [CH3NH3]+Pb2+(X−)3, where X = Cl, Br or I.
Methylammonium_lead_halide
Chemical compound
of Inorganic Compounds, CRC Press, p. 3315, ISBN 978-0-412-30120-9 Yamaguchi, O.; Sugiura, K.; Muto, M.; Shimizu, K. (June 1985). "Compound formation in
Lead_metagermanate
LEAD COMPOUND
LEAD COMPOUND
Surname or Lastname
English (chiefly Kent)
English (chiefly Kent) : from Middle English heved ‘head’, applied as a nickname for someone with some peculiarity or disproportion of the head, or a topographic name for someone who lived on a hill or at the head of a stream or valley. This surname has long been established in Ireland.
Surname or Lastname
English
English : possibly a metonymic nickname for a needy person, from Middle English ne(e)d ‘need’.Respelling of German Nied.
Surname or Lastname
English
English : from the Old English personal names Lēofa (masculine) and Lēofe (feminine) ‘dear’, ‘beloved’. These names were in part short forms of various compound names with this first element, in part independent affectionate bynames.English : apparently a topographic name for someone who lived in a densely foliated area, from Middle English lēaf ‘leaf’; a certain Robert Intheleaves is recorded in London in the 14th century.Americanized form of Swedish Lö(ö)f, Löv, an ornamental name from löv ‘leaf’.English translation of the Ashkenazic Jewish ornamental surname Blatt.
Female
English
 Variant spelling of Old English Lea, LEAH means "meadow." Compare with other forms of Leah.
Surname or Lastname
English
English : nickname for a person with red hair or a ruddy complexion, from Middle English re(a)d ‘red’.English : topographic name for someone who lived in a clearing, from an unattested Old English rīed, r̄d ‘woodland clearing’.English : Read in Lancashire, the name of which is a contracted form of Old English rǣghēafod, from rǣge ‘female roe deer’, ‘she-goat’ + hēafod ‘head(land)’; Rede in Suffolk, so called from Old English hrēod ‘reeds’; or Reed in Hertfordshire, so called from an Old English ryhð ‘brushwood’.English : A family called Read were established in America in the early 18th century by John Read, who was born in Dublin, sixth in descent from Sir Thomas Read of Berkshire, England. His son, George Read (1733–98), was one of the signers of the Declaration of Independence, and as a lawyer helped frame the Constitution.
Surname or Lastname
English
English : habitational name from any of various places in northern France named with the Germanic element lÄr ‘clearing’.English : variant of Layer.English : nickname from Old English hlÄ“or ‘cheek’, ‘face’Irish : reduced Anglicization of Gaelic Mac Giolla Uidhir ‘son of the swarthy lad’ or ‘son of the servant of Odhar’, a byname from odhar (genitive uidhir) ‘dun-colored’, ‘weatherbeaten’. Compare McAleer.
Girl/Female
Bengali, Danish, Finnish, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Swedish, Telugu
Lead
Surname or Lastname
Scottish and Irish
Scottish and Irish : possibly a reduced and altered form of McLeish.English : see Lees 2.Americanized form of German Lasch.
Female
English
(Λήδα) Greek name LEDA means "woman." In mythology, this is the name of the mother of Castor, Pollux and Helen.
Surname or Lastname
English (chiefly Devon)
English (chiefly Devon) : nickname for a thin or lean person, from Middle English lene ‘lean’ (Old English hlǣne).Irish : reduced Anglicized form of Gaelic Ó Liatháin (see Lehane).Reduced form of Scottish McLean.
Surname or Lastname
English
English : topographic name for someone who lived near a loud, rushing stream, Old English hl̄de, or a habitational name from Lead in West Yorkshire, which is named from Old English lǣd ‘water course’ or Old English hlēda ‘ledge’.
Female
Hebrew
 Variant spelling of Hebrew Leah, LEA means "weary." Compare with another form of Lea.
Female
Hebrew
(לֵ×ָה) Hebrew name LEAH means "weary." In the bible, this is the name of Jacob's first wife. Compare with other forms of Leah.
Male
Hebrew
(×ֶלְעַד) Contracted form of Hebrew El'adah, ELAD means "whom God puts on."
Male
English
English surname transferred to forename use, derived from an Old English byname, Red, READ means "red-headed or ruddy-complexioned."Â
Female
Greek
(Λήδα) Greek name LEDA means "woman." In mythology, this is the name of the mother of Kastor, Pollux and Helen.
Surname or Lastname
English
English : variant spelling of Leake.
Surname or Lastname
English
English : topographic name for someone who lived by a meadow, from Middle English mede ‘meadow’ (Old English mǣd).English : metonymic occupational name for a brewer or seller of mead (Old English meodu), an alcoholic beverage made by fermenting honey.
Female
English
 Old English name LEA means "meadow." Compare with another form of Lea.
Surname or Lastname
English, Spanish, and Portuguese
English, Spanish, and Portuguese : nickname for a loyal or trustworthy person, from Old French leial, Spanish and Portuguese leal ‘loyal’, ‘faithful (to obligations)’, Latin legalis, from lex, ‘law’, ‘obligation’ (genitive legis).
LEAD COMPOUND
LEAD COMPOUND
Female
English
Pet form of Irish Nóra, NOREEN means "honor, valor."
Girl/Female
Hindu
Universal, An Apsara or celestial
Biblical
perplexity
Girl/Female
Muslim/Islamic
Blessed
Boy/Male
English
Gift
Boy/Male
Arabic, Muslim
Courageous; Lion
Girl/Female
Indian
Sita
Girl/Female
Hindu, Indian
Goddess Saraswati
Boy/Male
Arabic, Finnish, Hindu, Indian, Sanskrit
The Whole World; Lake
Boy/Male
Greek
Befiended by Telemachus.
LEAD COMPOUND
LEAD COMPOUND
LEAD COMPOUND
LEAD COMPOUND
LEAD COMPOUND
a.
Lacking spirit; dull; lusterless; cheerless; as, dead eye; dead fire; dead color, etc.
v. t.
To go or to be in advance of; to precede; hence, to be foremost or chief among; as, the big sloop led the fleet of yachts; the Guards led the attack; Demosthenes leads the orators of all ages.
v. t.
To be at the head of; to put one's self at the head of; to lead; to direct; to act as leader to; as, to head an army, an expedition, or a riot.
imp. & p. p.
of Lead.
v. t.
To guide or conduct with the hand, or by means of some physical contact connection; as, a father leads a child; a jockey leads a horse with a halter; a dog leads a blind man.
n.
The act of leading or conducting; guidance; direction; as, to take the lead; to be under the lead of another.
v. t.
To place leads between the lines of; as, to lead a page; leaded matter.
imp. & p. p.
of Lead
n.
An article made of lead or an alloy of lead
v. t.
To tend or reach in a certain direction, or to a certain place; as, the path leads to the mill; gambling leads to other vices.
n.
Sheets or plates of lead used as a covering for roofs; hence, pl., a roof covered with lead sheets or terne plates.
imp. & p. p.
of Read
n.
A small cylinder of black lead or plumbago, used in pencils.
n.
A plummet or mass of lead, used in sounding at sea.
a.
Resembling lead.
v. t.
To conduct or direct with authority; to have direction or charge of; as, to lead an army, an exploring party, or a search; to lead a political party.
a.
Still as death; motionless; inactive; useless; as, dead calm; a dead load or weight.
n.
precedence; advance position; also, the measure of precedence; as, the white horse had the lead; a lead of a boat's length, or of half a second.
v. t.
To begin a game, round, or trick, with; as, to lead trumps; the double five was led.
v. t.
To cover, fill, or affect with lead; as, continuous firing leads the grooves of a rifle.