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Protein-coding gene in the species Homo sapiens
induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the INSIG2 gene. Insulin activates the human INSIG2 promoter in a process mediated
INSIG2
Protein-coding gene in the species Homo sapiens
Furthermore, morbid obesity is associated with a combination of FTO and INSIG2 single nucleotide polymorphisms. In 2009, variants in the FTO gene were
FTO_gene
Mammalian protein found in Homo sapiens
transcription factor is short-lived. When cholesterol levels rise, INSIG1 and INSIG2 retain the SCAP-SREBP complex in the ER membrane by preventing its incorporation
HMG-CoA_reductase
independently of the serum response factor. Insulin activated the human INSIG2 promoter in a process mediated by phosphorylated SAP1a. Sap1a is phosphorylated
SAP1a
Protein family
of INSIG-2a, a liver-specific transcript encoding the SREBP-1c inhibitor INSIG2. FGF21 has been shown to repress the transcription of sterol regulatory
Sterol regulatory element-binding protein
Sterol_regulatory_element-binding_protein
Relation between obesity and genetic factors
and D11S912 BMIQ5 16p13 near ATA41E04 BMIQ6 20pter-p11.2 near D20S482 INSIG2 2q14.1 FTO 16q12.2 Adults who were homozygous for a particular FTO allele
Genetics_of_obesity
Protein-coding gene in the species Homo sapiens
resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8. Melanin-concentrating hormone receptor GRCh38: Ensembl release
Melanin-concentrating hormone receptor 2
Melanin-concentrating_hormone_receptor_2
Protein-coding gene in the species Homo sapiens
Haberhausen M, et al. (2009). "Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic
SREBP cleavage-activating protein
SREBP_cleavage-activating_protein
P01308 7698 INSC HGNC:33116; Q1MX18 7699 INSIG1 HGNC:6083; O15503 7700 INSIG2 HGNC:20452; Q9Y5U4 7701 INSL3 HGNC:6086; P51460 7702 INSL4 HGNC:6087; Q14641
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
INSIG2
INSIG2
INSIG2
INSIG2
INSIG2
INSIG2
INSIG2
INSIG2
INSIG2