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Chemical compound
Iberdomide (CC-220) is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide
Iberdomide
Class of protein inhibiting drugs
PMID 41032400. Clinical trial number NCT04975997 for "Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib
Targeted_protein_degradation
Class of immunomodulatory drugs
thalidomide and its analogues (lenalidomide, pomalidomide, mezigdomide, iberdomide, and golcadomide). These drugs may also be referred to as 'Cereblon modulators'
Cereblon_E3_ligase_modulator
Chemical compound
"High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system"
Avadomide
Class of chemical compounds
transcription factors. (see also thalidomide, pomalidomide, mezigdomide, iberdomide, avadomide) CC-90009 [CRBN-GSPT1] Induces GSPT1 degradation via CRBN recruitment
Molecular_glue
Cancer originating in lymph nodes
monotherapy or in combination with other drugs such as lenalidomide, iberdomide, or golcadomide. While it is too soon to judge the long-term results of
Follicular_lymphoma
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