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HLA DR2

  • HLA-DR2
  • Antigen serotype

    HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This

    HLA-DR2

    HLA-DR2

    HLA-DR2

  • HLA-DR
  • Subclass of HLA-D antigens that consist of alpha and beta chains

    with certain HLA-DRB1 types. The HLA-DRB5 locus encodes the HLA-DR51 specificity, which is typically invariable, and is linked to the HLA-DR2 types. linkage

    HLA-DR

    HLA-DR

    HLA-DR

  • HLA-DR15
  • HLA-DR serotype

    Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens. Serotypes are unknown for the following

    HLA-DR15

    HLA-DR15

    HLA-DR15

  • Aplastic anemia
  • Disease causing insufficient blood cells of all types

    found dominant subpopulations characterized by higher expression of HLA-DR2 and HLA-DR15 (mean age of two groups: 34 and 21 years), FOXP3, CD95, and CCR4;

    Aplastic anemia

    Aplastic_anemia

  • Human leukocyte antigen
  • Genes on human chromosome 6

    The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation

    Human leukocyte antigen

    Human leukocyte antigen

    Human_leukocyte_antigen

  • HLA-DRB1
  • Protein-coding gene in the species Homo sapiens

    HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta

    HLA-DRB1

    HLA-DRB1

    HLA-DRB1

  • HLA-DR16
  • modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens. DR16 is associated with Chaga's

    HLA-DR16

    HLA-DR16

    HLA-DR16

  • HLA-DR1
  • Serotype of cell surface receptors

    HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians. The serology for the

    HLA-DR1

    HLA-DR1

    HLA-DR1

  • HLA-DR51
  • allele groups. HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 - DRB1*16 Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic

    HLA-DR51

    HLA-DR51

    HLA-DR51

  • HLA-DRA
  • Protein-coding gene in the species Homo sapiens

    HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit

    HLA-DRA

    HLA-DRA

    HLA-DRA

  • Anti-topoisomerase antibodies
  • Autoantibodies

    frequently HLA-DR2, and in another population study it was found that DR-15 is associated with ATA in systemic sclerosis. In addition to HLA-DR, the protein

    Anti-topoisomerase antibodies

    Anti-topoisomerase_antibodies

  • HLA B7-DR15-DQ6
  • follows: HLA Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 The older literature may describe this haplotype in two different ways. One B7-DR2-DQ6 derives

    HLA B7-DR15-DQ6

    HLA_B7-DR15-DQ6

  • HLA-DRB5
  • Protein-coding gene in the species Homo sapiens

    "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes". J. Immunol

    HLA-DRB5

    HLA-DRB5

    HLA-DRB5

  • Anti-SSA/Ro autoantibodies
  • Type of anti-nuclear autoantibodies

    immune response. Anti-Ro/SSA associates with the HLA II alleles HLA-DR3 and HLA-DR2, as well as some HLA-DQ alleles. The T-cell response plays a role in

    Anti-SSA/Ro autoantibodies

    Anti-SSA/Ro autoantibodies

    Anti-SSA/Ro_autoantibodies

  • Major histocompatibility complex, class II, DQ alpha 1
  • Protein-coding gene in the species Homo sapiens

    "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes". J. Immunol

    Major histocompatibility complex, class II, DQ alpha 1

    Major histocompatibility complex, class II, DQ alpha 1

    Major_histocompatibility_complex,_class_II,_DQ_alpha_1

  • Aphthous stomatitis
  • Medical condition of benign mouth ulcers forming periodically

    genetically predisposed to developing oral ulceration. HLA-B12, HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated

    Aphthous stomatitis

    Aphthous stomatitis

    Aphthous_stomatitis

  • Jack L. Strominger
  • American biochemist

    of HLA-A2, HLA-A68, and HLA-B27. Ultimately, papain-solubilized fragments of the human class II MHC antigens HLA-DR1, HLA-DR2, HLA-DR3, HLA-DR4, HLA-DR7

    Jack L. Strominger

    Jack_L._Strominger

  • Autoimmunity
  • Immune response against an organism's own healthy cells

    invaders, but may also give rise to lymphocytes capable of self-reactivity. HLA DR2 is strongly positively correlated with systemic lupus erythematosus, narcolepsy

    Autoimmunity

    Autoimmunity

    Autoimmunity

  • Myelin basic protein
  • Protein family

    MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES 1bx2: CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM

    Myelin basic protein

    Myelin basic protein

    Myelin_basic_protein

  • Acute posterior multifocal placoid pigment epitheliopathy
  • Eye disease causing lesions in retina

    accompanies it. It is associated with an increased incidence of both HLA-B7 and HLA-DR2.[citation needed] The underlying etiology of APMPPE continues to cause

    Acute posterior multifocal placoid pigment epitheliopathy

    Acute posterior multifocal placoid pigment epitheliopathy

    Acute_posterior_multifocal_placoid_pigment_epitheliopathy

  • HLA-DR11
  • PMID 16121403. Hu C, Wu C, Lee C, Wu C, Tsai H, Chen P, Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic

    HLA-DR11

    HLA-DR11

    HLA-DR11

  • List of MeSH codes (D23)
  • HLA-DR2 MeSH D23.050.301.500.410.400.440.455 – HLA-DR3 MeSH D23.050.301.500.410.400.440.460 – HLA-DR4 MeSH D23.050.301.500.410.400.440.465 – HLA-DR5

    List of MeSH codes (D23)

    List_of_MeSH_codes_(D23)

  • History and naming of human leukocyte antigens
  • Classification of leukocyte antigens

    Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing

    History and naming of human leukocyte antigens

    History_and_naming_of_human_leukocyte_antigens

  • Narinder Kumar Mehra
  • Indian immunologist (born 1949)

    in India, he studied HLA-linked genes and identified that a subtype of HLA-DR2 carried a unique class II haplotype which made humans susceptible to diseases

    Narinder Kumar Mehra

    Narinder Kumar Mehra

    Narinder_Kumar_Mehra

  • Dirucotide
  • Chemical compound

    disease progression for five years in progressive MS patients with HLA-DR2 or HLA-DR4 immune response genes. It does not seem to be effective in patients

    Dirucotide

    Dirucotide

    Dirucotide

  • IFN1@
  • Gene in the species Homo sapiens

    Wieczorek S, Dahmen N, Kasten M, et al. (2004). "A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon

    IFN1@

    IFN1@

  • Goodpasture syndrome
  • Rare autoimmune disease

    peak age ranges for the onset of the disease are 20–30 and 60–70 years. HLA-DR § DR2 Pulmonary-renal syndrome "Goodpasture Syndrome". www.hopkinsmedicine

    Goodpasture syndrome

    Goodpasture syndrome

    Goodpasture_syndrome

  • List of human leukocyte antigen alleles associated with cutaneous conditions
  • There are many human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system List of allergens List

    List of human leukocyte antigen alleles associated with cutaneous conditions

    List_of_human_leukocyte_antigen_alleles_associated_with_cutaneous_conditions

  • Anti-glycoprotein-210 antibodies
  • Isoform Nucleoporin 210kDa Autoantigen gene NUP210 Affected organ(s) Bile Duct Associated Disease(s) Primary biliary cirrhosis HLA associations DR2 (weak)

    Anti-glycoprotein-210 antibodies

    Anti-glycoprotein-210_antibodies

  • Immunologic adjuvant
  • Component of vaccines

    disease. It only affected people who have the HLA-DQB1*0602 variant of the HLA-DQB1 gene, also known as DR2+. 0.02% of *0602 carriers who took the vaccine

    Immunologic adjuvant

    Immunologic_adjuvant

  • Anti-p62 antibodies
  • Isoform Nucleoporin 62kDA Autoantigen gene NUP62 Affected organ(s) Bile duct Associated Disease(s) Primary biliary cirrhosis HLA associations DR2 (weak)

    Anti-p62 antibodies

    Anti-p62_antibodies

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