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Protein-coding gene in the species Homo sapiens
Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan
Heparin_cofactor_II
Process of formation of blood clots
(and related coumarins) and heparin are the most commonly used. Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX, X) and protein C
Coagulation
Mammalian protein found in Homo sapiens
binding site of thrombin. Antithrombin II (AT II) refers to a cofactor in plasma, which together with heparin interferes with the interaction of thrombin
Antithrombin
Superfamily of proteins with similar structures and diverse functions
allosteric interactions with specific cofactors. The X-ray crystal structures of antithrombin, heparin cofactor II, MENT and murine antichymotrypsin reveal
Serpin
Pharmaceutical drug
potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously. Clinically, sulodexide is used for the prophylaxis
Sulodexide
Pharmaceutical compound
heparin cofactor II, which prevent clotting when it is not necessary. In contrast, batroxobin is not inhibited by antithrombin and heparin cofactor II
Batroxobin
Enzyme involved in blood coagulation in humans
C-terminal trypsin-like serine protease domain. Factor Xa with factor V as a cofactor leads to cleavage of the Gla and two Kringle domains (forming together
Thrombin
Mammalian protein found in Homo sapiens
Fibronectin, Gentamicin, GIPC1, Heat shock proteins: gp96, hsp70, hsp90, heparin cofactor II, Hepatic lipase, ITGB1BP1, Lactoferrin, Lipoprotein lipase, LPL,
LRP1
776.377.715.085.394 – haptoglobins MeSH D12.776.377.715.085.450 – heparin cofactor ii MeSH D12.776.377.715.085.640 – orosomucoid MeSH D12.776.377.715.085
List_of_MeSH_codes_(D12.776)
Thrombophilia due to elevated HRG; 613116; HRG Thrombophilia due to heparin cofactor II deficiency; 612356; HCF2 Thrombophilia due to HRG deficiency; 613116;
List_of_OMIM_disorder_codes
Mammalian protein found in Homo sapiens
activity. Heparin (unfractionated heparin) and its derivatives low molecular weight heparin (LMWH) bind to a plasma cofactor, antithrombin (AT) to inactivate
Factor_X
Type of cascade reaction of the complement system
2005). "Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with
Alternative complement pathway
Alternative_complement_pathway
Protein-coding gene in the species Homo sapiens
PMID 2164060. Pratt CW, Tobin RB, Church FC (April 1990). "Interaction of heparin cofactor II with neutrophil elastase and cathepsin G". The Journal of Biological
Cathepsin_G
Medical condition
vitamin K-dependent physiological anticoagulant, acts as a nonenzymatic cofactor to activate protein C in the degradation of factor Va and factor VIIIa
Protein_S_deficiency
Active form of vitamin B6
stored in granularity in mast cells as a complex with acid residues of heparin proteoglycan while in basophils as a complex with chondroitine sulfate
Pyridoxal_phosphate
Glycosaminoglycan found in animals
sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor. Dermatan+sulfate at the U.S. National Library of Medicine Medical
Dermatan_sulfate
Class of enzymes
sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese. As of late 2007, 4 structures have been solved for this class
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Galactosylgalactosylxylosylprotein_3-beta-glucuronosyltransferase
776.124.790.106.394 – haptoglobins MeSH D12.776.124.790.106.450 – heparin cofactor ii MeSH D12.776.124.790.106.640 – orosomucoid MeSH D12.776.124.790.106
List of MeSH codes (D12.776.124)
List_of_MeSH_codes_(D12.776.124)
Complex that catalyzes conversion of prothrombin to thrombin
complex consists of factor Xa (a serine protease) and factor Va (a protein cofactor). The complex assembles on negatively charged phospholipid membranes in
Prothrombinase
Protein-coding gene in humans
(2005). "Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with
CFHR5
Mammalian protein found in Homo sapiens
cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. LPL is attached to the luminal surface of endothelial cells in capillaries
Lipoprotein_lipase
Enzyme in human blood that degrades clots and other proteins
Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase plasminogen activator receptor (uPAR) is a cofactor for plasminogen
Plasmin
Drug discovery
to cofactors like antithrombin to inhibit thrombin so they can both inhibit free/soluble thrombin as well as fibrin bound thrombin unlike heparins. The
Discovery and development of direct thrombin inhibitors
Discovery_and_development_of_direct_thrombin_inhibitors
Drugs for heart or blood vessels diseases
antithrombin. Heparin is a widely used anticoagulant. It is administered intravenously (into a vein) or subcutaneously (below the skin). Heparin can exert
Cardiovascular_agents
Human disease caused by a lack of vitamin B3
Matz, H.; Tüzün, Y.; Tüzün, B. (2002). "Miscellaneous treatments, II: Niacin and heparin: Unapproved uses, dosages, or indications". Clinics in Dermatology
Pellagra
Chemical element with atomic number 16 (S)
metabolites—many of which are cofactors—and sulfated polysaccharides of connective tissue (chondroitin sulfates, heparin). The functionality of a given
Sulfur
Group of vitamins and bacterial metabolites
revealed to be much more complex. K vitamins play an essential role as cofactor for the enzyme γ-glutamyl carboxylase, which is involved in vitamin K-dependent
Vitamin_K2
Protein found in humans
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated
PLCG1
exosite I and exosite II and their locations on thrombin. Exosite I primarily is a fibrinogen-binding site, and exosite II is a heparin-binding site. Studies
Exosite
Protein-coding gene in the species Homo sapiens
chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma
XYLT2
Enzyme in neutrophils and other immune cells
during the neutrophil's defensive respiratory burst. It requires heme as a cofactor. Furthermore, it oxidizes tyrosine to tyrosyl radical using hydrogen peroxide
Myeloperoxidase
Abnormality of blood coagulation increasing the risk of blood clotting (thrombosis)
skin and migraine). Heparin-induced thrombocytopenia (HIT) is due to an immune system reaction against the anticoagulant drug heparin (or its derivatives)
Thrombophilia
Class of enzymes
families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which
Superoxide_dismutase
Peptide hormone
reactive oxygen species inhibits the insulin gene by interfering with the cofactors binding the transcription factors and the transcription factors itself
Insulin
Protein-coding gene in the species Homo sapiens
Ohkubo I, Murachi T, Sasaki M (May 1987). "Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy
Kininogen_1
Protein found in humans
available to date indicates that CCP modules 1–4 is responsible for the cofactor and decay acceleration activities of factor H, whereas self/non-self discrimination
Factor_H
Group of signal transduction pathways involved in embryonic development
(February 2017). "A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation". Science Signaling
Wnt_signaling_pathway
Hypersensitivity reaction to a food
Skypala IJ (2019). "Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors". Frontiers in Immunology. 10 673. doi:10.3389/fimmu.2019.00673. PMC 6457317
Food_allergy
Immune system protein
et al. (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry
CCR5
700.350.500.500 – chondroitin abc lyase MeSH D08.811.520.241.700.512 – heparin lyase MeSH D08.811.520.241.700.675 – hyaluronoglucosaminidase MeSH D08
List_of_MeSH_codes_(D08)
HEPARIN COFACTOR-II
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