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Search references for HDAC7. Phrases containing HDAC7
See searches and references containing HDAC7!HDAC7
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. Multiple alternatively spliced transcript variants encoding several isoforms
HDAC7
Pharmaceutical compound
(IC50 = >80,000 nM). Potential actions against other HDACs, such as HDAC4, HDAC7, HDAC8, and HDAC9, were not described. The drug has been found to enhance
Tianeptinaline
Pharmaceutical compound
inhibitory concentration (nM) HDAC1 58 HDAC2 48 HDAC3 51 HDAC4 7,000 HDAC5 5,000 HDAC6 4.7 HDAC7 1,400 HDAC8 100 HDAC9 >10,000 HDAC10 ND HDAC11 >10,000 Refs:
Ricolinostat
Pharmaceutical compound
no inhibition of several other HDACs, including HDAC4, HDAC5, HDAC6, and HDAC7. RGFP136 has been found to enhance long-term memory in rodents, which led
RGFP136
Pharmaceutical compound
was observed. Activities at the class I HDAC8 and at the class IIb HDAC4, HDAC7, and HDAC9 were not assessed nor described. The pharmacokinetics of neurinostat
Neurinostat
Pharmaceutical compound
over other HDACs, with IC50 values of 2,000 to 5,000 nM at HDAC1, HDAC2, HDAC7, and HDAC8 and no significant inhibition of other HDACs including HDAC3
CKD-506
Pharmaceutical compound
I HDAC8, with no significant inhibition of the class IIa HDAC4, HDAC5, HDAC7, or HDAC9. The drug has been found to robustly activate CREB-mediated transcription
Crebinostat
Pharmaceutical compound
HDAC2 3,010–17,680 HDAC3 80–401 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >100,000 HDAC9 >20,000 HDAC10 >20,000 HDAC11 >20,000 Refs:
RGFP966
Medication used for epilepsy, bipolar disorder and migraine
HDAC1 3.94–35.5 HDAC2 59.3 HDAC3 218.5 HDAC4 >15,000 HDAC5 >15,000 HDAC6 >20,000 HDAC7 >15,000 HDAC8 1.59–97.1 HDAC9 >15,000 HDAC10 ND HDAC11 ND Refs:
Valproate
Pharmaceutical compound
concentration (nM) HDAC1 1 HDAC2 8–13 HDAC3 398–458 HDAC4 >33,000 HDAC5 >33,000 HDAC6 >33,000 HDAC7 >33,000 HDAC8 >33,000 HDAC9 >33,000 HDAC10 3,400 Refs:
BRD-6929
Pharmaceutical compound
41–636 HDAC2 147–696 HDAC3 46–472 HDAC4 >33,000 HDAC5 >33,000 HDAC6 >33,000 HDAC7 >33,000 HDAC8 >33,000 HDAC9 >33,000 HDAC10 >10,000 HDAC11 >10,000 Refs:
Tacedinaline
Chemical compound (CH3CH2CH2COOH)
000 Lower bound HDAC5 2,000,000 Lower bound HDAC6 2,000,000 Lower bound HDAC7 2,000,000 Lower bound HDAC8 15,000 HDAC9 2,000,000 Lower bound CA1 511,000
Butyric_acid
Biological processes used in gene regulation
HDACs includes HDAC4, HDAC5, HDAC7 and HDAC9. HDACs 4 and 5 have been found to most closely resemble each other while HDAC7 maintains a resemblance to both
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Chemical compound
(μM) HDAC1 5,300 HDAC2 ND HDAC3 2,400 HDAC4 4,500 HDAC5 ND HDAC6 48,500 HDAC7 ND HDAC8 ND HDAC9 ND HDAC10 ND HDAC11 ND Note: BHB can circulate at mM levels
Β-Hydroxybutyric_acid
Pharmaceutical compound
HDAC1 1,510 HDAC2 750 HDAC3 96 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >20,000 HDAC9 >20,000 HDAC10 6,640–10,000 HDAC11 27,700 Refs:
RGFP963
Chemical compound
HDAC1 133–198 HDAC2 293–325 HDAC3 136–157 HDAC4 1,059 HDAC5 532 HDAC6 312–315 HDAC7 524 HDAC8 837–854 HDAC9 512–541 HDAC10 331–340 HDAC11 287–292 Refs:
Givinostat
Enzyme found in humans
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal
Histone_deacetylase_5
Compounds that inhibit histone deacetylases
μM) of selected HDAC inhibitors Drug HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 Refs Butyric acid (butyrate) 8.3 7.0 4.8 5,725
Histone_deacetylase_inhibitor
Class of enzymes important in regulating DNA transcription
skeletal muscle, brain GCMA, SMAD7, HP1 REA, estrogen receptor Cardiac defect HDAC7 1 Nucleus / cytoplasm / mitochondria heart, skeletal muscle, pancreas, placenta
Histone_deacetylase
Protein found in humans
22 MAPK13 5.37E-06 0.0149 6p21.31 RBM4 9.36E-06 0.0202 11q13.2 NYNRIN 3.04E-05 0.0328 14q12 HDAC7 7.1E-05 0.0486 12q13.11 ZNF675 7.25E-05 0.0486 19p12
CCDC188
Chemical compound
concentration (nM) HDAC1 0.3 HDAC2 0.8–2.0 HDAC3 0.6 HDAC4 1,970 HDAC5 352 HDAC6 4.1 HDAC7 >20,000 HDAC8 >15,000 HDAC9 >15,000 HDAC10 ND HDAC11 ND Refs:
Martinostat
Pharmaceutical drug
(nM) HDAC1 1–48 HDAC2 2–73 HDAC3 3–21 HDAC4 >25,000 HDAC5 >15,000 HDAC6 0.5–100 HDAC7 >25,000 HDAC8 290–1,410 HDAC9 >25,000 HDAC10 60 HDAC11 31 Refs:
Vorinostat
Chemical compound
inhibitory concentration (nM) HDAC1 4.99 HDAC2 2.7 HDAC3 5.21 HDAC4 27.6 HDAC5 776 HDAC6 16.4 HDAC7 482 HDAC8 486 HDAC9 >1,000 HDAC10 24.3 HDAC11 >1,000 Refs:
Trichostatin_A
Protein-coding gene in the species Homo sapiens
PMC 1223570. PMID 12737628. Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream
KAT5
Protein-coding gene in the species Homo sapiens
endothelin receptor type A". Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream
Endothelin_A_receptor
Protein-coding gene in the species Homo sapiens
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal
HDAC9
Gene regulation in autoimmune diseases
binding protein p300, and HDAC1. There were also decreased levels of HDAC2, HDAC7, and LSD1 expression shown in the peripheral blood mononuclear cells. A
Epigenetics of autoimmune disorders
Epigenetics_of_autoimmune_disorders
Pharmaceutical compound
HDAC2 306–753 HDAC3 248–1,577 HDAC4 >100,000 HDAC5 >30,000 HDAC6 >100,000 HDAC7 >30,000 HDAC8 2,700–82,500 HDAC9 >30,000 HDAC10 94,700 HDAC11 >10,000 Refs:
Entinostat
Protein-coding gene in the species Homo sapiens
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal
Histone_deacetylase_2
P56524 6966 HDAC5 HGNC:14068; Q9UQL6 6967 HDAC6 HGNC:14064; Q9UBN7 6968 HDAC7 HGNC:14067; Q8WUI4 6969 HDAC8 HGNC:13315; Q9BY41 6970 HDAC9 HGNC:14065;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Protein-coding gene in the species Homo sapiens
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal
HDAC1
Protein-coding gene in humans
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". Journal
HDAC3
Protein-coding gene in the species Homo sapiens
proteolytic cleavage. MEF2C has been shown to interact with: EP300, HDAC4, HDAC7, HDAC9, MAPK7, SOX18 SP1, and TEAD1. SETD1A This gene is involved in cardiac
MEF2C
Field of study
HDAC1, HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, class III, consisting of NAD+-dependent HDACS, and class
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Protein-coding gene in the species Homo sapiens
Kasler H, McKinsey TA, et al. (2005). "Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation". J. Biol
PRKD2
Protein found in humans
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal
HDAC4
Protein found in humans
F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol
Nuclear receptor co-repressor 1
Nuclear_receptor_co-repressor_1
HDAC7
HDAC7
HDAC7
HDAC7
HDAC7
HDAC7
HDAC7
HDAC7
HDAC7