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Protein-coding gene in the species Homo sapiens
Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of proteins, which are believed
Gamma-synuclein
Protein family
electric ray. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began
Synuclein
Protein found in humans
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle
Alpha-synuclein
Progressive neurodegenerative disease
related cell groups in the brainstem. Misfolded proteins, such as alpha-synuclein, aggregate to form clumps called Lewy bodies, if not cleared from cells
Parkinson's_disease
Protein-coding gene in the species Homo sapiens
properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins". The Journal of
Beta-synuclein
Diseases caused by abnormal protein structure
"Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide". Journal of Alzheimer's Disease. 24 (Suppl
Proteinopathy
MeSH D12.776.641.650.460.075 – beta-msh MeSH D12.776.641.650.460.115 – gamma-msh MeSH D12.776.641.650.575.180 – dynorphins MeSH D12.776.641.650.575.241
List of MeSH codes (D12.776.641)
List_of_MeSH_codes_(D12.776.641)
Group of disorders
express FD-cell markers (e.g. CD21, CD23, CD35, clusterin, podoplanin, gamma-synuclein) and in >90% of cases products of the virus's EBER and LMLP1 genes
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Chemical compound
models and appears to be partly responsible for elevated phosphorylated α-synuclein levels, as improving the function of this complex causes both AKG and
Α-Ketoglutaric_acid
Central nervous system disease
Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. Membrane damage by alpha-synuclein could be another Parkinson's disease
Neurodegenerative_disease
Protein-coding gene in the species Homo sapiens
homeostasis. APLP1 has also been implicated in the transmission pathologic α-synuclein in Parkinson's disease GRCh38: Ensembl release 89: ENSG00000105290 – Ensembl
APLP1
American neurologist and neuroscientist
prominent role in the pathogenesis of Parkinson's disease due to pathologic α-synuclein. They discovered the parkin substrate, PARIS, which plays a key pathogenic
Ted_M._Dawson
Progressive neurodegenerative disease
Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein". Science. 349 (6248) 1255555. doi:10.1126/science.1255555. PMID 26250687
Alzheimer's_disease
Type of cytotoxic lymphocyte
disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein aggregates, destroy senescent neurons, and attenuate the neuroinflammation
Natural_killer_cell
Field of study
alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and fibrillar accumulation of Lewy bodies from misfolded alpha-synuclein.
Epigenetics of neurodegenerative diseases
Epigenetics_of_neurodegenerative_diseases
Group of six protein isoforms produced from the MAPT gene
in iPSC-derived cortical neurons revealed a higher expression of alpha-synuclein compared to H2H2, which may explain the association of haplotype with
Tau_protein
Extracellular deposits of the amyloid beta protein
(September 2002). "Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's
Amyloid_plaques
as well as filaments of Amyloid beta from Alzheimer's disease, Alpha-synuclein from Multiple system atrophy and TMEM106B. Scheres has been a member of
Sjors_Scheres
Protein-coding gene in the species Homo sapiens
and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin
Tubulin_alpha-1A_chain
Cell surface receptor found in humans
pathology-associated proteins such as aggregates of amyloid-βpeptides (Aβ) or α-synuclein. All these structures bind TLR4 and activate downstream signaling pathways
Toll-like_receptor_4
American physician (born 1943)
PMC 2702130. PMID 18568035. Bartels T, Choi JG, Selkoe DJ (2011). "alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation"
Dennis_J._Selkoe
Physiological nature of sleep
mainly when they are characterized by abnormal accumulation of alpha-synuclein, such as multiple system atrophy (MSA), Parkinson's disease (PD) and Lewy
Neuroscience_of_sleep
Protein-coding gene in the species Homo sapiens
Meisinger C, Sigrist SJ, Madeo F (Nov 2013). "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". The EMBO Journal. 32 (23): 3041–54
ENDOG
Mammalian protein found in humans
Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E (March 2008). "alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
cells. LAG3 has also been implicated in the transmission pathologic α-synuclein in Parkinson's disease There are three approaches involving LAG3 that
Lymphocyte-activation_gene_3
Family of proteins which attach to other proteins to modify them
accumulating proteins which threaten neurodegenerative disorders include α-synuclein (associated with Parkinson's) and Amyloid β (associated with Alzheimer's)
SUMO_protein
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
that yeast models of Parkinson's are more susceptible to toxicity from α-synuclein, the major protein component of Lewy bodies, under conditions of low proteasome
Proteasome
Endogenous tag expressed in different cells along neurogenesis and differentiated cells
and reactive astrocytes. Neuron specific enolase (NSE), also called as gamma-enolase or enolase 2, is a cytosolic protein that is expressed in mature
Neuronal_lineage_marker
Membrane proteins that adhere temporarily to membranes with which they are associated
Archived from the original on 2007-09-26. Retrieved 2007-01-25. "Pfam entry Synuclein". Archived from the original on 2007-09-26. Retrieved 2007-01-25. "Pfam
Peripheral_membrane_protein
regions against brain diseases (19 Apr). Progress in screening: an α-synuclein SAA (assay) against Parkinson's disease (12 Apr), and exogenously administered
2023_in_science
Protein-coding gene in the species Homo sapiens
KE, Amore AM, et al. (July 2007). "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. 317 (5837)
Sirtuin_2
Protein-coding gene in the species Homo sapiens
proteostasis processes, which involves breaking down protein aggregations like a-synuclein which accumulates in Parkinson's disease. A study found that damaging
DNAJC28
Protein-coding gene in the species Homo sapiens
Liscovitch N, French L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease"
Ankyrin-1
Protein-coding gene in the species Homo sapiens
G, Fernández-Chacón R, Schlüter OM, Südhof TC (November 2005). "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration". Cell. 123 (3):
DNAJC5
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
Surname or Lastname
English
English : variant of Game.English : from Anglo-Norman French gambon ‘ham’, a diminutive of gambe, Norman-Picard form of Old French jambe ‘leg’ (Late Latin gamba), hence probably a nickname for someone with some peculiarity of the legs or gait.
Girl/Female
Gujarati, Hindu, Indian
The Soothing Voice
Girl/Female
Danish, Indian, Latin, Sanskrit, Swedish
Loveable; Desire
Girl/Female
Hindu, Indian, Kannada, Telugu
Beautiful; A Destiny
Boy/Male
Indian
Supreme god.
Girl/Female
African, American, Australian, British, Chinese, Christian, Danish, Dutch, English, French, German, Irish, Italian, Jamaican, Latin
Jewel; Precious Stone; Gem
Female
English
Italian name GEMMA means "precious stone."
Girl/Female
Hebrew
Without flaw.
Girl/Female
Australian, French, Hebrew
Without Flaw; Palm Tree; Perfect
Boy/Male
Arabic
Two Bright Stars Near the Pole; Beta and Gama in Ursa Minor
Boy/Male
African, British, English, Indian
Mother; God-like
Girl/Female
Arabic, Indian, Kashmiri
Beautiful Sky
Girl/Female
Norse
Grandmother.
Girl/Female
French Latin Italian
Jewel.
Girl/Female
Tamil
Beautiful, A destiny
Surname or Lastname
German
German : East Frisian patronymic from the nursery name Mamme, linked to Middle High German mamme, memme ‘mother’s breast’ (Latin mamma).English (of Norman origin) : from the Old French personal name Maismon, Maimon, of unknown etymology.Indian (Kerala) : variant of Thomas among Kerala Christians, with the Tamil-Malayalam third person masculine singular suffix -n. It is only found as a personal name in Kerala, but in the U.S. has come to be used as a family name among Kerala Christians.
Female
English
Variant spelling of Italian Gemma, JEMMA means "precious stone."
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN
GAMMA SYNUCLEIN