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Search references for EXON. Phrases containing EXON
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Region of a transcribed gene present in the final functional mRNA molecule
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The
Exon
Molecular mechanism for the formation of new genes
Exon shuffling is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought
Exon_shuffling
Tandem exon duplication is defined as duplication of exons within the same gene to give rise to the subsequent exon. A complete exon analysis of all genes
Tandem_exon_duplication
Topics referred to by the same term
Look up exon in Wiktionary, the free dictionary. Exon may refer to: Exon, a region of DNA that is represented in the mature form of RNA Exoribonuclease
Exon_(disambiguation)
Australian rules footballer
Natalie Exon (born 7 December 1992) is an Australian rules footballer who most recently played for the Hawthorn Football Club in the AFL Women's. Exon was
Nat_Exon
American politician (1921–2005)
John James Exon (August 9, 1921 – June 10, 2005) was an American businessman and politician who served as the 33rd governor of Nebraska from 1971 to 1979
J._James_Exon
Form of RNA splicing used to cause cells to "skip" over faulty sections of genetic code
molecular biology, exon skipping is a form of RNA splicing used to cause cells to “skip” over faulty or misaligned sections (exons) of a gene, leading
Exon_skipping
Biological phenomenon
Poison exons (PEs); also called premature termination codon (PTC) exons or nonsense-mediated decay (NMD) exons] are a class of cassette exons that contain
Poison_exon
Process by which a gene can code for multiple proteins
For example, some exons of a gene may be included within or excluded from the final RNA product of the gene. This means the exons are joined in different
Alternative_splicing
United States Air Force general
War II fighter pilot, Exon was a recipient of the Distinguished Service Cross. Exon was born in 1916 in Geddes, South Dakota. Exon attended high school
Arthur_Exon
Protein complex assembled on mRNA
An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together
Exon_junction_complex
DNA sequence motif
splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous nuclear RNA
Exonic_splicing_enhancer
Exon trapping is a molecular biology technique to identify potential exons in a fragment of eukaryote DNA of unknown intron-exon structure. This is done
Exon_trapping
1989 industrial disaster in Alaska
The Exxon Valdez oil spill was a major environmental disaster that occurred in Alaska's Prince William Sound on March 24, 1989. The spill occurred when
Exxon_Valdez_oil_spill
election in Nebraska was held on November 5, 1990. Incumbent Senator J. James Exon ran for re-election to a third term. He was challenged by Republican nominee
1990 United States Senate election in Nebraska
1990_United_States_Senate_election_in_Nebraska
Type of muscular dystrophy
muscular dystrophy is caused by mutations or deletions in any of the 79 exons encoding the large dystrophin protein, which is essential for maintaining
Duchenne_muscular_dystrophy
Monoclonal antibody
specific types of genetic mutations: epidermal growth factor receptor (EGFR) exon 20 insertion mutations. The most common side effects include rash, infusion-related
Amivantamab
Manuscript originating with the Domesday Survey of 1086
The Liber Exoniensis or Exon Domesday is the oldest of the three manuscripts originating with the Domesday Survey of 1086, covering south-west England
Liber_Exoniensis
splicing silencer (ESS) is a short region (usually 4-18 nucleotides) of an exon and is a cis-regulatory element. A set of 103 hexanucleotides known as FAS-hex3
Exonic_splicing_silencer
Database of spliced mRNA sequences
The Exon-Intron Database (EID) is a database of spliced mRNA sequences. Alternative splicing Exon Intron Saxonov, S; Daizadeh I; Fedorov A; Gilbert W
Exon-intron_database
Process in molecular biology
all the introns (non-coding regions of RNA) and splicing back together exons (coding regions). For nuclear-encoded genes, splicing occurs in the nucleus
RNA_splicing
Medical condition
heterozygous mutations have been identified along various locations of the exon on the P450 arom (CYP19) gene localized on chromosome15p21.1. In addition
Aromatase_deficiency
United States law regulating foreign investment
The Exon–Florio Amendment 50 U.S.C. app 2170 is a law that was enacted by the United States Congress in 1988 to review foreign investment within the United
Exon–Florio_Amendment
Small domesticated carnivorous mammal
color variety in the coat. The feline ASIP gene consists of three coding exons. Three novel microsatellite markers linked to ASIP were isolated from a
Cat
American academic administrator and politician (born 1972)
Class 2 Thayer P. Hitchcock Saunders Manderson Thurston Millard Brown Norris Wherry Seaton Griswold Bowring Abel Curtis Exon Hagel Johanns Sasse Ricketts
Ben_Sasse
Nebraska was held on November 6, 1984. Incumbent Democratic Senator J. James Exon ran for re-election to a second term. He was challenged by Nancy Hoch, the
1984 United States Senate election in Nebraska
1984_United_States_Senate_election_in_Nebraska
Anti-cancer medication
non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or exon 21 L858R substitution mutations. Efficacy was evaluated in MARIPOSA
Lazertinib
Rare genetic disorder
1248+1G>T) next to exon 12 of the KMT2E gene causes exon 12 to be skipped during RNA splicing, joining exon 11 directly to exon 13 (instead of exon 12). This creates
O'Donnell-Luria–Rodan syndrome
O'Donnell-Luria–Rodan_syndrome
20th and 21st-century Bishop of Exeter; Bishop of Birkenhead
Michael Laurence Langrish (born 1 July 1946) is a retired English Anglican bishop. He was Bishop of Exeter from 2000 to 2013. Langrish was born in Southampton
Michael_Langrish
Pharmaceutical drug
locally advanced or metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping mutation. Gumarontinib is a selective MET—hepatocyte growth factor
Gumarontinib
10th-century book of Anglo-Saxon poetry
The Exeter Book, also known as the Codex Exoniensis or Exeter Cathedral Library MS 3501, is a large codex of Old English poetry, believed to have been
Exeter_Book
protein by selecting for poison exons during alternative splicing. SR proteins can alternatively splice poison exons into their own mRNA transcripts to
SR_protein
Chemical compound, used as a medication to treat lung cancer
inhibitors, such as gefitinib, erlotinib, and afatinib. In the US, EGFR exon 19 deletions, exon 21 L858R mutations, or the T790M status of the patient must be
Osimertinib
Chemical compound
(NSCLC) with MET exon 14 skipping mutations. Hong L, Zhang J, Heymach JV, Le X (2021). "Current and future treatment options for MET exon 14 skipping alterations
Vebreltinib
Philip of Exon was Archdeacon of Barnstaple until 1279. "Memorials of Barnstaple; being an attempt to supply the want of a history of that ancient borough"
Philip_of_Exon
mutations including exon skipping, intron retention, and cryptic splice site activation. A splice site defines the boundary between a coding exon and a non-coding
Shapiro–Senapathy_algorithm
Class of drugs
from a class of pyridazine small molecules and enhances the inclusion of exon 7, resulting in a full-length and functional protein product.[citation needed]
RNA-targeting small molecule drugs
RNA-targeting_small_molecule_drugs
Rare genetic disorder
in the exons encoding the type III repeats (exons 8–14) and C-terminal domain (exons 15–19). The most common mutations in COL9A1 are in exons 8-10, in
Multiple_epiphyseal_dysplasia
Lab technique in cellular biology
miRNA, tRNA, and ribosomal profiling. RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene
RNA-Seq
Sequence of DNA that determines traits in an organism
open reading frames contain untranslated introns, which are removed and exons, which are connected together in a process known as RNA splicing. Finally
Gene
1978 BBC radio play
deadly Exon plant strain's advancement continues. Search and Destroy – Despite the national emergency, landowners try to profit from the deadly Exon strain
The_Destruction_Factor
A minigene is a minimal gene fragment that includes an exon and the control regions necessary for the gene to express itself in the same way as a wild
Minigene
Protein fragment in Homo sapiens
to encode the full receptor protein. This mature mRNA is composed of exons. Exons are peptide encoding regions of DNA genes that remain in the transcript
Growth hormone-binding protein
Growth_hormone-binding_protein
Medical condition
change G6PD-A(+) Gd-A(+) G6PD A +305900.0001 Polymorphism nucleotide A→G 376 (Exon 5) 126 Asparagine→Aspartic acid (ASN126ASP) No enzyme defect (variant) G6PD-A(-)
Glucose-6-phosphate dehydrogenase deficiency
Glucose-6-phosphate_dehydrogenase_deficiency
stop codons. The short ORFs could have contained the short protein-coding exons observed in eukaryotic genes, whereas the intervening sequences with numerous
Split_gene_theory
Form of evolutionary mutation
always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence
Synonymous_substitution
*rōbos-to- > rōbustus "oaken" (cf. rōbur "oak" < *rōbos) Exon's law, named after Charles Exon, dictates that if there are two light medial syllables in
History_of_Latin
American politician and naval officer (born 1943)
seniority) 101st Senate: ▌J. J. Exon (D) ▌B. Kerrey (D) House: ▌V. Smith (R) ▌D. Bereuter (R) ▌P. Hoagland (D) 102nd Senate: ▌J. J. Exon (D) ▌B. Kerrey (D) House:
Bob_Kerrey
Carl Curtis declined to seek re-election to a fifth term. Governor J. James Exon won the Democratic nomination uncontested and then faced Republican Donald
1978 United States Senate election in Nebraska
1978_United_States_Senate_election_in_Nebraska
Medication
mRNA.[citation needed] If an exon with an appropriate number of bases lies near the mutation, by removing the defective exon the downstream reading frame
Eteplirsen
Enzyme and protein-coding gene in humans
alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced
UGT1A4
Software program to identify complete gene structures in genomic DNA
GHMM-based program that can be used to predict the location of genes and their exon-intron boundaries in genomic sequences from a variety of organisms. The GENSCAN
GENSCAN
Mutation at a location where intron splicing takes place
RNA into mature messenger RNA. Splice site consensus sequences that drive exon recognition are located at the very termini of introns. The deletion of the
Splice_site_mutation
Uniform Polytope
on the end of the 2-node sequence. Pentacontahexa-pentacosiheptacontahexa-exon (Acronym: laq) - 56-576 facetted polyexon (Jonathan Bowers) It is created
2_31_polytope
Synthetic promoter in gene expression
cytomegalovirus (CMV) early enhancer element, (A) the promoter, the first exon and the first intron of chicken beta-actin gene, (G) the splice acceptor
CAG_promoter
Protein-coding gene in humans
gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in
GRIN1
Trans-Spliced Exon Coupled RNA End Determination (TEC-RED) is a transcriptomic technique that, like SAGE, allows for the digital detection of messenger
Trans-Spliced Exon Coupled RNA End Determination
Trans-Spliced_Exon_Coupled_RNA_End_Determination
Protein-coding gene in the species Homo sapiens
Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which
MAGOH
Different products from the same gene
ability to select different protein-coding segments (exons) of a gene, or even different parts of exons from RNA to form different mRNA sequences. Each unique
Isoform
Protein-coding gene in the species Homo sapiens
encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance
RNPS1
Medical condition
4-base pair deletion de novo mutation in exon 3 in the SON gene and de novo 2-base point insertion in exon, resulting in haploinsufficiency or a frameshift
ZTTK_syndrome
Insect protein
removed, exon 3 encoded segment reverses the structural transformation and outputs the energy to exon 1 encoded segment. Another secondary structure exon 1 and
Resilin
Genetic disorder of the skull and face
342 in exon 9, which creates a gain-of-function. The FGFR2lllc isoform, created via alternative splicing of exon 3 of the FGFR2 gene, uses exon 9 and is
Crouzon_syndrome
Medication
cell lung cancer with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations, as detected by an FDA-approved
Amivantamab/hyaluronidase
Medical condition
These mutations are in exon 8 (type 2) and exon 8a (classical form, type 1). Exons 8 and 8A are mutually exclusive exons. Exon 8a is highly expressed
Timothy_syndrome
Protein-coding gene in the species Homo sapiens
SMG6 gene resides on chromosome 17 at the band 17p13.3 and contains 30 exons. This gene produces 3 isoforms through alternative splicing. SMG6 is one
SMG6
Medication
who have a confirmed mutation of the dystrophin gene that is amenable to exon 45 skipping. It is an antisense oligonucleotide of phosphorodiamidate morpholino
Casimersen
Pharmaceutical drug
metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations, as detected by an FDA-approved test, whose disease
Sunvozertinib
Protein-coding gene in the species Homo sapiens
chromosome (10p14). It is oriented on the plus strand of DNA and has 5 exons. The orthologous space for PROSER2 is fairly large, as 143 organisms are
Proline and serine-rich protein 2
Proline_and_serine-rich_protein_2
American heavy strategic bomber
motion to end the project—as well as others in the Senate, including Jim Exon (D-NE) and John McCain (R-AZ) also opposing the project. Dellums and Kasich
Northrop_B-2_Spirit
Gerald T. Whelan. Incumbent Governor J. James Exon, a Democrat, was barred from seeking a third term. Exon was elected to the U.S. Senate that same day
1978 Nebraska gubernatorial election
1978_Nebraska_gubernatorial_election
Prehistoric monument in England
Stonehenge (The British Academy 92, Oxford University Press, 1997) Exon et al., Sally Exon, Vincent Gaffney, Ann Woodward, Ron Yortson, Stonehenge Landscapes:
Stonehenge
Protein-coding gene in the species Homo sapiens
alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced
UGT1A10
Biochemistry detection method
Nucleic Acid Research. The first applications included the detection of exon deletions in the human genes BRCA1, MSH2 and MLH1, which are linked to hereditary
Multiplex ligation-dependent probe amplification
Multiplex_ligation-dependent_probe_amplification
Medication for treatment of non-small-cell lung cancer
in the epidermal growth factor receptor (EGFR) — either an exon 19 deletion (del19) or exon 21 (L858R) substitution mutation — which has spread to other
Erlotinib
Species of bear
T1R1 and T1R3), resulting from two frameshift mutations within the T1R1 exons. Umami taste corresponds to high levels of glutamate as found in meat and
Giant_panda
Protein-coding gene in the species Homo sapiens
alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced
UGT1A7
Chemical compound
Drisapersen alters the splicing of the dystrophin RNA transcript, eliminating exon 51 from the mature dystrophin mRNA. Drisapersen is an antisense oligonucleotide
Drisapersen
Protein-coding gene in the species Homo sapiens
nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop
UPF3A
1996 federal law attempting to regulate Internet pornography
Act of 1996, as specified in Section 501 of that statute. Senators James Exon and Slade Gorton introduced an initial bill to the Senate Committee of Commerce
Communications_Decency_Act
Small molecule tyrosine kinase inhibitor
target is epidermal growth factor receptor (EGFR) bearing mutations in the exon 20 region. Mobocertinib is an irreversible kinase inhibitor, forming a covalent
Mobocertinib
Protein-coding gene in the species Homo sapiens
family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with
OR2L2
Group of transport proteins
NKCC1/Slc12a2 gene result from keeping (isoform 1) or skipping (isoform 2) exon 21 in the final gene product. NKCC1 is widely distributed throughout the
Na–K–Cl_cotransporter
American politician (1928–1987)
Zorinsky Federal Building". Archived from the original on July 24, 2010. Sen. Exon, J. James [D-NE (June 27, 1988). "S.1960 - 100th Congress (1987-1988): A
Edward_Zorinsky
James Exon, a Democrat, defeating incumbent Republican governor Norbert Tiemann. Julius W. Burbach, member of the Nebraska Legislature James Exon, businessman
1970 Nebraska gubernatorial election
1970_Nebraska_gubernatorial_election
Topics referred to by the same term
combining stepping and hopping A game or form of exercise using a skipping rope Exon skipping, in molecular biology Stone skipping, throwing a stone so that it
Skipping
Chemical compound
non-small cell lung cancer whose tumors have a mutation that leads to the exon 14 skipping of the MET gene, which codes for the membrane receptor HGFR.
Capmatinib
Largest known protein in human muscles
titin contains the largest number of exons (363) discovered in any single gene, as well as the longest single exon (17,106 bp). In 1954, Reiji Natori proposed
Titin
Protein-coding gene in humans
part of the visible spectrum (long-wavelength light). The gene contains 6 exons with variability that induces shifts in the spectral range. OPN1LW is subject
OPN1LW
Australian molecular biologist and academic
muscular dystrophy (DMD). Their research led to the development of three exon-skipping compounds that have received approval from the US FDA for restoring
Steve_Wilton
This is a list of genes, proteins or receptors named A1 or Alpha-1 : Actin, alpha 1 Actinin, alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Protein-coding gene in the species Homo sapiens
followed by exon 2, a small intron then exon 3. The rest of the protein follows exon 3 with a large intron, exon 4 a small intron then exon 5, the 3' UTR
TMEM249
Protein-coding gene in the species Homo sapiens
spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMC 305905
ALYREF
Maturation process joining exons from different pre-mRNAs into a mature mRNA
Trans-splicing is a special form of RNA processing where exons from two different primary RNA transcripts are joined end to end and ligated. It is usually
Trans-splicing
Form of treatment for genetic disorders and other illnesses
ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA. Several ASOs
Antisense_therapy
DNA mutation with no observable effect on an organism's phenotype
not always silent. The multi-drug resistance genes at Exon 26 C3435T, exon 21 G2677T/A, and exon 12 C1236T have been studied to have SNP's that occur at
Silent_mutation
Modification in mRNA, DNA
mRNA is controlled by exon architecture and exon junction complexes. Exon junction complexes suppress m6A methylation near exon-exon junctions by packaging
N6-Methyladenosine
Protein-coding gene in the species Homo sapiens
humans is encoded by the ZNF649 gene on Human Chromozone 19 containing 5 exons. GRCh38: Ensembl release 89: ENSG00000198093 – Ensembl, May 2017 "Human
ZNF649
Protein-coding gene in the species Homo sapiens
two alternatively spliced 5' untranslated exons. These two transcripts contain the same eight coding exons, and therefore, encode the same protein. GRCh38:
MFAP2
American professor of medicine
Bennett Lorber Portrait of Bennett Lorber by Randall Exon, 2014 Born (1943-04-01) April 1, 1943 (age 83) Philadelphia, Pennsylvania, United States Education
Bennett_Lorber
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