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Protein-coding gene in Drosophila melanogaster
Doubletime (DBT), also known as discs overgrown (DCO), is a gene that encodes the doubletime protein in fruit flies (Drosophila melanogaster). Michael
Doubletime_(gene)
American biologist and geneticist (born 1949)
Young's lab is also attributed with the discovery of the timeless and doubletime genes, which makes proteins that are also necessary for circadian rhythm
Michael_W._Young
Topics referred to by the same term
in the Building Doubletime, a 2007 documentary film about rope skipping Double time, a rate of pay during overtime Doubletime (gene) Double time, a marching
Double_Time
Protein and coding gene in humans
CK1ε, is an enzyme that is encoded by the CSNK1E gene in humans. It is the mammalian homolog of doubletime. CK1ε is a serine/threonine protein kinase and
Casein kinase 1 isoform epsilon
Casein_kinase_1_isoform_epsilon
Family of protein kinases
CK1ε isoform was first implicated as a clock gene when its Drosophila homolog, double-time (Doubletime (gene)), was discovered in 1998. Double-time is 86%
Casein_kinase_1
Gene located on the X chromosome of Drosophila melanogaster
presence of light. When TIM is not complexed with PER, another protein, doubletime, or DBT, phosphorylates PER, targeting it for degradation. In mammals
Period_(gene)
American geneticist
of the circadian genes timeless (tim) and doubletime (dbt), and the doubletime regulators spaghetti (SPAG) and bride of doubletime (BDBT). Price was
Jeffrey_L._Price
Human protein and coding gene
essentially blocking per and tim transcription. CLK is hyperphosphorylated when doubletime (DBT) kinase interacts with the CLK-CYC complex in a PER reliant manner
CLOCK
Aschoff's First Rule expression is regulated by circadian genes, and mutation of relevant genes causes Aschoff's rule violation. Scientists had begun to
Aschoff's_Rules
and his team discovered the gene timeless (tim) that influences the activity of per. In 1998, they discovered doubletime (dbt), which regulate the amount
Drosophila_circadian_rhythm
Natural internal process that regulates the sleep-wake cycle
the per and tim genes. But their proteins levels remain low until dusk, because during daylight also activates the doubletime (dbt) gene. DBT protein causes
Circadian_rhythm
American medical investigator (born 1951)
synteny with the human genome. This revealed that the gene is closely related to the gene doubletime (dbt) in Drosophila, and casein kinase 1 epsilon (CKIe)
Joseph_Takahashi
accumulate slowly in the cytoplasm, where PER is phosphorylated by the kinase DOUBLETIME (DBT). The post-transcriptional modification of multiple phosphate groups
Transcription translation feedback loop
Transcription_translation_feedback_loop
American guitarist (born 1952)
Theater"; Athens News Courier Newspaper Archives May 15, 2011 Page 26 "DoubleTime: The Musical | New Play Exchange". newplayexchange.org. Retrieved December
Nile_Rodgers
Facundo Ponce de León, Juan Ponce de León Lucila Bortagaray, Ramón Cardini Doubletime 2007 Stephanie Johnes Alexandra Johnes, Stephanie Johnes, Andrea Meditch
List_of_documentary_films
American chronobiologist (1934–2021)
synteny was the gene casein kinase I epsilon (CKIe). This is consistent with CKIe's homology to the Drosophila circadian control gene doubletime (dbt). From
Michael_Menaker
Type of cysteine protease
Gerdes B, Fan JY, Bjes ES, Price JL (May 2015). "Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy"
Death regulator Nedd2-like caspase
Death_regulator_Nedd2-like_caspase
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