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Chemical compound
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to
Cycloguanil
Medication used to treat malaria and babesiosis
+ artemether# halofantrine Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene
Quinine
Chemical compound
breastfeeding. Proguanil is converted by the liver to its active metabolite, cycloguanil. It was removed from the World Health Organization's List of Essential
Proguanil
Chemical compound
process required for DNA replication. Proguanil, via its metabolite cycloguanil, functions as a dihydrofolate reductase inhibitor, halting parasitic
Atovaquone/proguanil
Chemical compound
compounds in water. Pharmaceutical drugs formulated this way include cycloguanil pamoate, hydroxyzine pamoate, imipramine pamoate, olanzapine pamoate
Pamoic_acid
Chemical compound
dihydrofolate reductase. Examples include:[citation needed] Proguanil (>cycloguanil) Chlorproguanil The disinfectants chlorhexidine, polyaminopropyl biguanide
Biguanide
Pharmaceutical drug
+ artemether# halofantrine Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene
Primaquine
Chemical compound
+ artemether# halofantrine Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene
Piperaquine
Cellular enzyme inhibitor
JPC-2056 Oral piritrexim, a treatment for metastatic urothelial cancer. Cycloguanil, a metabolite of proguanil (a component of the oral antimalarial atovaquone-proguanil
Dihydrofolate reductase inhibitor
Dihydrofolate_reductase_inhibitor
cyclobutoic acid (INN) cyclobutyrol (INN) Cyclocort cyclofenil (INN) cycloguanil embonate (INN) Cyclogyl Cyclomen. Redirects to Danazol. cyclomenol (INN)
List_of_drugs:_Cp–Cz
Pharmaceutical drug classification
Primaquine P01BA06 Amodiaquine P01BA07 Tafenoquine P01BB01 Proguanil P01BB02 Cycloguanil embonate P01BB51 Proguanil and atovaquone P01BB52 Chloroquine and proguanil
ATC_code_P01
Agents used in the treatment of malaria
but primarily is mediated through conversion to the active metabolite cycloguanil. This inhibits the malarial dihydrofolate reductase enzyme. Its most
Antimalarial_medication
British chemist
cyclization of this prodrug led to the active dihydrotriazine derivative cycloguanil (the mechanism of its work is still debated). He was elected a Fellow
Frank_Rose_(chemist)
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