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Protein
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein
Complement_factor_I
Part of the immune system that enhances the ability of antibodies and phagocytic cells
of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H-related
Complement_system
Protein-coding gene in the species Homo sapiens
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway
Complement_factor_B
Topics referred to by the same term
Factor I may refer to: Complement factor I, a protein of the complement system Fibrinogen, a protein involved in blood coagulation Factor 1, a component
Factor_I
Type of cascade reaction of the complement system
called complement factor I cleaves C3b into its inactive form, iC3b. Factor I requires a C3b-binding protein cofactor such as complement factor H, CR1
Alternative complement pathway
Alternative_complement_pathway
Protein found in humans
Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein
Factor_H
Class of enzymes
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein
Factor_D
Medical condition
Molecular Basis of Primary Deficiencies of Complement Component C3 and its Regulatory Proteins Factor I and Factor H". Scandinavian Journal of Immunology
Complement_3_deficiency
Human chromosome
encoding protein Cytokine dependent hematopoietic cell linker Complement Factor I: Complement Factor I COL25A1-DT: encoding protein Zinc finger, cchc domain containing
Chromosome_4
Protein found in humans
agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway
Complement_component_3
Protein
over. ClfA also interacts with complement factor I, an enzyme that cleaves C3b into its inactive form, iC3b. When factor I is recruited to the bacterial
Clumping_factor_A
Protein part of the complement system
complement factor I cleaves C3b. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin. Unlike intact C3b, iC3b cannot
IC3b
Disease of blood and kidneys after bacterial infection
for several complement regulatory proteins. Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3, and
Hemolytic–uremic_syndrome
Topics referred to by the same term
global brokerage firm CFI, a human gene that encodes the protein complement factor I Color Fidelity Index, a measure for color rendering developed by
CFI
regulated without C3b inactivation, through complement control proteins, including decay-accelerating factors that function to speed up C3 convertase half-lives
C3a_(complement)
Protein involved in the immune system
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system
Complement_component_4
Protein found in humans
It is also important to note that Complement component 2 deficiency can be caused by genetic and environmental factors. In genetic inheritance, Autosomal
Complement_component_2
Protein-coding gene in humans
Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene. GRCh38: Ensembl release 89: ENSG00000244414 – Ensembl
CFHR1
Genetic process
Complementation refers to the capacity of a segment of genetic material (eg DNA) to rescue the phenotype of a mutation. It shows that a copy of the gene
Complementation_(genetics)
Life-threatening immune-related blood disease
failure, and death. The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane cofactor
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Protein-coding gene in the species Homo sapiens
encoded by the CFP (complement factor properdin) gene. Properdin and factor H are regulatory proteins in the alternative complement pathway. Properdin
Properdin
Class of serine proteases
of complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B
C3-convertase
Myosin Binding Protein H (MYBPH)
than its paralogs (MYBPHL and MyBPC), cytochrome C, and fibrinogen complement factor 1. MYBPH contributes to sarcomere organization and striated muscle
MYBPH
Mammalian protein found in Homo sapiens
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
British protein biochemist, immunologist, and academic
affecting complement activation and inflammation in AMD. His work further revealed that the AMD-associated 402H variant of complement factor H binds less
Simon_J._Clark
Protein domain
Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains);
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
Vision loss due to damage to the macula of the eye
CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, et al. (July 2006). "Complement factor H polymorphism, complement activators, and risk of age-related
Macular_degeneration
Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin
Macrophage-1_antigen
Chemical compound
treatment of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth.
Iptacopan
corresponding to a general complement is called the internal Zappa–Szép product. When H and K are nontrivial, complement subgroups factor a group into smaller
Complement_(group_theory)
Medical condition
deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative C3 convertase
Properdin_deficiency
Protein found in humans
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system
Complement_component_1s
Part of the innate immune system
C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b
C3b
Protein-coding gene in the species Homo sapiens
APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene. Alternative splicing occurs at this locus and three full-length
A1CF
Crewed full ocean depth rated submersible
Limiting Factor, known as Bakunawa since its sale in 2022, and designated Triton 36000/2 by its manufacturer, is a crewed deep-submergence vehicle (DSV)
DSV_Limiting_Factor
Human cancer-testis antigen protein
humans. MAGEB17 diverges more rapidly than both Cytochrome c and Complement factor I, suggesting relatively weak purifying selection on the protein sequence
MAGEB17
Protein-coding gene in the species Homo sapiens
humans is encoded by the C4B gene. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed
Complement_component_4B
Protein found in humans
of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane
Complement_receptor_1
611721; PSAP Complement component 4, partial deficiency of; 120790; C1NH Complement factor H deficiency; 609814; HF1 Complement factor I deficiency; 610984;
List_of_OMIM_disorder_codes
920.325.200 – complement factor h MeSH D12.776.124.486.274.920.325.210 – complement factor i MeSH D12.776.124.486.274.920.662 – complement c4b-binding protein
List of MeSH codes (D12.776.124)
List_of_MeSH_codes_(D12.776.124)
classical-complement-pathway C3/C5 convertase EC 3.4.21.44: Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: complement factor I EC
List_of_EC_numbers_(EC_3)
Clumping of abnormal cold-sensitive proteins in blood
cryoglobulinemic disease have rheumatoid factor activity, meaning they bind to polyclonal immunoglobulins and activate the blood complement system. They therefore form
Cryoglobulinemia
Overreaction of the immune system to an antigen
a major risk factor for developing systemic lupus erythematosus. This is believed to be due to the fact that in the absence of complement components, immune
Hypersensitivity
Complex exponential in terms of sine and cosine
i: i 0 = 1 , i 1 = i , i 2 = − 1 , i 3 = − i , i 4 = 1 , i 5 = i , i 6 = − 1 , i 7 = − i ⋮ ⋮ ⋮ ⋮ {\displaystyle {\begin{aligned}i^{0}&=1,&i^{1}&=i,&i^{2}&=-1
Euler's_formula
Global conflict from 1914 to 1918
Command to force Allied soldiers out of their entrenched positions, complementing rather than supplanting more lethal conventional weapons. Chemical weapons
World_War_I
Medical condition
glomerular mesangium and basement membrane (GBM) thickening, activating the complement system and damaging the glomeruli. MPGN accounts for approximately 4%
Membranoproliferative glomerulonephritis
Membranoproliferative_glomerulonephritis
760.198 – complement factor b MeSH D08.811.277.656.300.760.200 – complement factor d MeSH D08.811.277.656.300.760.210 – complement factor i MeSH D08.811
List_of_MeSH_codes_(D08)
Quantity in relativistic physics
The Lorentz factor or Lorentz term (also known as the gamma factor) is a dimensionless quantity expressing how much the measurements of time, length, and
Lorentz_factor
Mammalian protein found in humans
bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released by macrophages, T cells and
C-reactive_protein
Proteins similar to insulin that stimulate cell proliferation
be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor, it can also complement for the effects
Insulin-like_growth_factor
Protein fragment
mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system such as sepsis, rheumatoid
Complement_component_5a
Mammalian protein found in humans
(through cleavage) of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. The protein encoded
Membrane_cofactor_protein
Dietary theory for protein nutrition
Protein combining or protein complementing is a dietary theory for protein nutrition that purports to optimize the biological value of protein intake
Protein_combining
Activation of coagulation cascade
In the contact activation system or CAS, three proteins in the blood, factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK), bind
Contact_activation_system
Mammalian protein found in humans
most markedly lupus erythematosus, due to its consumptive effect on complement factors 3 and 4. Mutations in the gene that codes for C1-inhibitor, SERPING1
C1-inhibitor
Complexity class
complexity class. A decision problem X is a member of co-NP if and only if its complement X is in the complexity class NP. The class can be defined as follows:
Co-NP
Number format for specifying provision
can be seen as a 16-bit signed (two's complement) integer, that is implicitly multiplied by the scaling factor 2 − 12 {\displaystyle 2^{-12}} . In particular
Q_(number_format)
Statistical measure in mathematical model
In statistics, the variance inflation factor (VIF) is the ratio (quotient) of the variance of a parameter estimate when fitting a full model that includes
Variance_inflation_factor
Subset with finite complement
subset of a set X {\displaystyle X} is a subset A {\displaystyle A} whose complement in X {\displaystyle X} is a finite set. In other words, A {\displaystyle
Cofiniteness
Standard for miniature computer expansion cards
2 (pronounced "em-dot-two"), formerly known as the Next Generation Form Factor (NGFF), is a specification for internally mounted computer expansion cards
M.2
Mathematical concept
Lagrangian. The complement operation exchanges isotropic and coisotropic subspaces of complementary dimensions. In particular, any line is complemented to a hyperplane
Symplectic_vector_space
Protein-coding gene in humans
Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene. GRCh38: Ensembl release 89: ENSG00000134365 – Ensembl
CFHR4
Protein-coding gene in the species Homo sapiens
is encoded by the C4A gene. This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed
C4A
Negative integer two units from the origin in mathematics
can be factored as i × ( 1 + i ) 2 {\displaystyle i\times (1+i)^{2}} , where 1 + i {\displaystyle 1+i} is a Gaussian prime and i {\displaystyle i} is the
−2
{\displaystyle \complement _{A}B=A\setminus B} . 2. Without a subscript, denotes the absolute complement; that is, ∁ A = ∁ U A {\displaystyle \complement A=\complement
Glossary of mathematical symbols
Glossary_of_mathematical_symbols
Form of musical chord
common factors present in the V9 chord," with the 5th, "typically omitted". The ninth and seventh usually resolve downward to the fifth and third of I. Example
Ninth_chord
Overview of and topical guide to immunology
C9 Complement pathway inhibitors C1-inhibitor - Classical, Lectin, Alternate Decay-accelerating factor (CD59) - Classical, Lectin, Alternate Factor I -
Outline_of_immunology
Mathematical set formed from two given sets
sets in { X i } i ∈ I {\displaystyle \{X_{i}\}_{i\in I}} is defined to be ∏ i ∈ I X i = { f : I → ⋃ i ∈ I X i | ∀ i ∈ I . f ( i ) ∈ X i } , {\displaystyle
Cartesian_product
Protein-coding gene in the species Homo sapiens
1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochemical and Biophysical
MASP1
Autoimmune disease in which the immune system attacks healthy tissue
they are smaller or scarce and die earlier. Serum components like complement factors, CRP, and some glycoproteins are, furthermore, decisively important
Lupus
Disease characterized by rapid swelling
reduced complement factor C4, rather than the C1-INH deficiency itself, that is detected. The former is used during the reaction cascade in the complement system
Angioedema
Video-sharing platform
June, with US$4.99 channel subscriptions. These channel subscriptions complemented the existing Super Chat ability, launched in 2017, which allows viewers
YouTube
Computer format for representing real numbers
fixed-point formats as a signed integer in two's complement representation with an implicit scaling factor as above. The sign of the value will always be
Fixed-point_arithmetic
Immunity strategy in living beings
infection sites by producing chemical factors, including chemical mediators called cytokines activate the complement cascade to identify bacteria, activate
Innate_immune_system
Group of proteins in vertebrates
those of class I and class II. The gene cluster was discovered when genes (specifically those of complement components C2, C4, and factor B) were found
MHC_class_III
Medical condition
pharynx or the skin, given the time required to raise antibodies and complement proteins. The infection causes blood vessels in the kidneys to develop
Acute proliferative glomerulonephritis
Acute_proliferative_glomerulonephritis
Generalised alphabetical order
sign takes some time). This is one of the reasons for adopting two's complement representation for representing signed integers in computers. Another
Lexicographic_order
Standard for multi-factor authentication
Universal 2nd Factor (U2F) is an open standard that strengthens and simplifies two-factor authentication (2FA) using specialized Universal Serial Bus
Universal_2nd_Factor
Omitted words still understood in context
been to Russia than I have been to Russia". Null complement anaphora elides a complete complement, whereby the elided complement is a finite clause, infinitive
Ellipsis_(linguistics)
American football league
Incoming co-owner Mike Repole described his goal for the UFL as to "complement(...) the NFL and rid(e) off their momentum(,)" "not looking to compete
United Football League (2024–present)
United_Football_League_(2024–present)
Legendary war in Greek mythology
; Rapp, G. (Rip); Kayan, I.; Luce, J. V. (2003). "Harbor areas at ancient Troy: Sedimentology and geomorphology complement Homer's Iliad". Geology. 31
Trojan_War
Epic poem attributed to Homer
two-word stock epithet (e.g., "resourceful Odysseus") reiteration may complement a character name by filling a half-line, thus freeing the poet to compose
Iliad
American sitcom (1951–1957)
however, that Ball, who had previously been a blonde, dyed her hair red to complement the Technicolor features that MGM planned to use her in. MGM cast Ball
I_Love_Lucy
About polynomials in several variables
pole along a complex line, but on the complement of that line it defines a two-sheeted étale cover of the complement of a discriminant curve in C 2 {\displaystyle
Jacobian_conjecture
Similarity measure for number sequences
distance metric and can be calculated from the cosine similarity. The complement of the angular distance metric can then be used to define angular similarity
Cosine_similarity
Protein Domain
vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV;
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
One of the four basic arithmetic operations
ones' complement is very easily obtained by inverting each bit (changing "0" to "1" and vice versa). And adding 1 to get the two's complement can be
Subtraction
Learning aid for mathematics
unit cube rather than 1 cm (0.4 in). She produced various resources to complement the rods, such as trays to arrange the rods in, and tracks to arrange
Cuisenaire_rods
Medication
It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins
Danicopan
Protein domain
degrades type I and IV collagen and fibronectin in the presence of calcium. Mammalian complement-activating component of Ra-reactive factor (RARF), a protease
CUB_domain
American actor (born 1973)
In 2012, he co-hosted the second season of the American version of The X Factor with Khloé Kardashian, and was the sole host for the third and final season
Mario_Lopez
Pattern-recognition performance metrics
recall is simply the complement of the type II error rate (i.e., one minus the type II error rate). Precision is related to the type I error rate, but in
Precision_and_recall
with intraocular lens placement CF cystic fibrosis CFA complement-fixing antibody colonization factor antigen CFIDS chronic fatigue immune dysfunction syndrome
List of medical abbreviations: C
List_of_medical_abbreviations:_C
Knot which lies on the surface of a torus in 3-dimensional space
{\displaystyle t^{(p-1)(q-1)/2}{\frac {1-t^{p+1}-t^{q+1}+t^{p+q}}{1-t^{2}}}.} The complement of a torus knot in the 3-sphere is a Seifert-fibered manifold, fibred
Torus_knot
Theorem in group theory
subgroup N {\displaystyle N} of a finite group G {\displaystyle G} has a complement in G {\displaystyle G} . Moreover if either N {\displaystyle N} or G /
Schur–Zassenhaus_theorem
Seventh Universe. Whis adds that both the Seventh and Sixth Universes complement each other as their designated numbers add to thirteen. After Vados discovers
List of Dragon Ball Super episodes
List_of_Dragon_Ball_Super_episodes
mannose and N-acetylglucosamine. The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed
Mannan-binding lectin-associated serine protease-2
Mannan-binding_lectin-associated_serine_protease-2
American actress and singer (1977–2009)
her creativity, and she considered her mother a crucial factor in her later success: "When I asked my mom to move to California, she sold everything and
Brittany_Murphy
American mass murderer (1941–1991)
McClemont, W. F. (March 12, 1966). "Criminal patients with XYY sex-chromosome complement". Lancet. 287 (7437): 565–6. doi:10.1016/S0140-6736(66)90760-4. PMID 4159988
Richard_Speck
2026 South Korean television series
emotional shifts, blending a masculine presence with a softer quality that complements his acting. Jo Su-jin of Joynews24 focused on Joo Ho-jin's styling, noting
Can_This_Love_Be_Translated?
COMPLEMENT FACTOR-I
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