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Topics referred to by the same term
CGMP is an initialism. It can refer to: cyclic guanosine monophosphate (cGMP) current good manufacturing practice (cGMP) CGMP, Cisco Group Management
CGMP
Manufacturing quality standards
Current good manufacturing practices (cGMP) are those conforming to the guidelines recommended by relevant agencies. Those agencies control the authorization
Good_manufacturing_practice
Drug for erectile dysfunction and hypertension
blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. It requires sexual arousal to work
Sildenafil
Chemical compound
Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic
Cyclic guanosine monophosphate
Cyclic_guanosine_monophosphate
Mammalian protein found in humans
belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis. The interest in PDEs as molecular targets of drug action has
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Protein kinase
cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number
CGMP-dependent_protein_kinase
Family of transport proteins
can be the result of a combination of the binding of cyclic nucleotides (cGMP and cAMP) and either a depolarization or a hyperpolarization event. Initially
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Amino acid metabolic disorder
is casein glycomacropeptide (CGMP), which is a milk peptide naturally free of Phe in its pure form.[citation needed] CGMP can substitute for the main part
Phenylketonuria
Process by which light activates retinal cells
within the cGMP-gated cation channels more sensitive to low cGMP levels (thereby, keeping the cGMP-gated cation channel open even at low cGMP levels, restoring
Visual_phototransduction
Lyase enzyme that synthesizes cGMP from GTP
cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell. Like cAMP, cGMP is an important second
Guanylate_cyclase
Medical condition
CNGB3 function or gain of function—often increased affinity for cGMP—of CNGA3. cGMP levels are controlled by the activity of the cone cell transducin
Achromatopsia
Drug discovery
platelets. It is possible to prevent cGMP hydrolysis by inhibiting PDE5 and therefore treat diseases associated with low cGMP levels; because of this, PDE5 is
Discovery and development of phosphodiesterase 5 inhibitors
Discovery_and_development_of_phosphodiesterase_5_inhibitors
Class of enzymes
degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide
Phosphodiesterase
The following is a list of phosphodiesterase inhibitors. Adibendan Aminophylline Aminophylline dihydrate Amipizone Apremilast Arofylline Atizoram Befuraline
List of phosphodiesterase inhibitors
List_of_phosphodiesterase_inhibitors
Medication used to treat erectile dysfunction
monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells.[medical citation needed] cGMP relaxes smooth muscle and increases blood flow
Tadalafil
Photoreceptor cells that can function in lower light better than cone cells
the activation of cGMP phosphodiesterase, which hydrolyzes cGMP (the second messenger), breaking it down into 5'-GMP. Reduction in cGMP allows the ion channels
Rod_cell
Chemical compound
cyclic GMP. Within certain cells the enzyme guanylyl cyclase makes cGMP from GTP. cGMP plays an important role in mediating hormonal signaling. GMP was
Guanosine_monophosphate
Protein-coding gene in the species Homo sapiens
humans is encoded by the PDE11A gene. The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways
PDE11A
Cardiac hormone which increases renal sodium excretion
receptor causes the conversion of GTP to cGMP and raises intracellular cGMP. As a consequence, cGMP activates a cGMP-dependent kinase (PKG or cGK) that phosphorylates
Atrial_natriuretic_peptide
System of communication
cGMP Regulation of Kinases and channels- Diverse actions Cytoplasmic Guanylyl cyclase Nitric Oxide (Nitric oxide receptor) cGMP Regulation of cGMP Gated
Cell_signaling
Vasodilating drug
is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle
PDE5_inhibitor
Enzyme and protein-coding gene in humans
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. Various cellular responses are
PDE10A
rapid decrease in cGMP levels in the granulosa cells and the oocytes through the gap junctions. PDE5 is also activated, increasing cGMP hydrolysis. In mouse
Resumption_of_meiosis
–O– linkage between phosphoric acid and two other compounds
acyl carrier proteins, phospholipids and the cyclic forms of GMP and AMP (cGMP and cAMP). Phosphodiester bonds make up the backbones of DNA and RNA. In
Phosphodiester_bond
Protein domain
species. The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure
GAF_domain
Heterotrimeric G protein involved in vertebrate phototransduction
α-subunit activates cGMP phosphodiesterase. cGMP phosphodiesterase breaks down cGMP, an intracellular second messenger which opens cGMP-gated cation channels
Transducin
Type of neuroepithelial cell
transducin then activates the enzyme cGMP-specific phosphodiesterase (PDE). PDE then catalyzes the hydrolysis of cGMP to 5' GMP. This is the second amplification
Photoreceptor_cell
Physiological phenomenon involving the engorgement of the clitoris
(2004). The neurovascular mechanism of clitoral erection: Nitric oxide and cGMP‐stimulated activation of BKCa channels. The FASEB journal, 18(12), 1382-1391
Clitoral_erection
Colorless gas with the formula NO
oxide pathway by protecting cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum
Nitric_oxide
Product providing additional nutrients
Good Manufacturing Practices (CGMP) and labeling with science-based ingredient descriptions and advertising. When finding CGMP or advertising violations,
Dietary_supplement
US government message type
the award of federal contracts. If current good manufacturing practice (cGMP) violations are cited, it adds a statement regarding the potential impact
FDA_warning_letter
Defunct Indian pharmaceutical manufacturer
Toansa facility, which concluded on 11 January 2014, identified significant cGMP violations. These included Toansa staff retesting raw materials, intermediate
Ranbaxy_Laboratories
Protein-coding gene in the species Homo sapiens
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene. PDE6A encodes the cyclic-GMP (cGMP)
PDE6A
Drug
cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this enzyme
Phosphodiesterase_inhibitor
Increased blood pressure in lung arteries
formation of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). The cGMP then activates cGMP-dependent kinase or PKG (protein kinase
Pulmonary_hypertension
Medication
guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). Among other roles, cGMP serves as a substrate for a cGMP-dependent protein kinase that
Nitroglycerin_(medication)
Medicinal therapy product manufacturer
services (CDMO) for Advanced Therapy Medicinal Products (ATMPs), utilizing cGMP standards. Operating in Europe and North America, the company specializes
SCTbio
Documents observations in inspections
Dispute Resolution: Scientific and Technical Issues Related to Pharmaceutical CGMP, and they have 30 calendar days to do so. The FDA refers to cellular and
Form_FDA_483
Response of the eye to light and dark
Under scotopic conditions, intracellular cGMP concentration is high in photoreceptors. cGMP binds to and opens cGMP gated Na+ channels to allow sodium and
Adaptation_(eye)
Drug mixture used mainly to treat ADHD and narcolepsy
for marketing purposes. The FDA cited the company for numerous significant CGMP violations related to Obetrol discovered during routine inspections following
Adderall
Arteries of the penis
monophosphate (cGMP). cGMP in turn triggers relaxation of the smooth muscle and results in dilation of blood vessels. This signal is terminated when cGMP is broken
Helicine_arteries_of_penis
Chemical compound
to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms
Guanosine
High blood pressure in the pulmonary arteries
vessels by inhibiting the degradation of Cyclic guanosine monophosphate (cGMP). cGMP inhibits pulmonary artery smooth muscle proliferation and causes pulmonary
Pulmonary arterial hypertension
Pulmonary_arterial_hypertension
Part of the epithalamus
Xiong, Wei-Hong; Solessio, Eduardo C.; Yau, King-Wai (1998). "An unusual cGMP pathway underlying depolarizing light response of the vertebrate parietal-eye
Parietal_eye
Anticholinergic used in the treatment of asthma
guanosine monophosphate (cGMP), resulting in a decreased intracellular concentration of cGMP. Most likely due to actions of cGMP on intracellular calcium
Ipratropium_bromide
Drug that causes vasodilation by releasing nitric oxide
Guanylate cyclase produces cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). cGMP in turn activates cyclic nucleotide-dependent protein
Nitrovasodilator
Medication for lowering blood pressure
It works by increasing nitric oxide levels in the blood, which increases cGMP levels in cells, and causes dilation of blood vessels. Sodium nitroprusside
Sodium_nitroprusside
Hormone secreted in the heart
collecting duct of the nephron via guanosine 3',5'-cyclic monophosphate (cGMP) dependent phosphorylation of ENaC. BNP and NT-proBNP are measured by immunoassay
Brain_natriuretic_peptide_32
Enzyme
isoforms. The various isoforms exhibit different affinities for cAMP and cGMP. The existence of the Ca2+-stimulated Phosphodiesterase 1 was first demonstrated
PDE1
Medicine
doses. Activation of GC-C increases cyclic guanosine monophosphate (cGMP). Elevated cGMP stimulates secretion of chloride and bicarbonate and water into the
Linaclotide
Cell division producing haploid gametes
cyclic guanosine 3′,5′-monophosphate (cGMP) in concert with natriuretic peptide receptor 2 (NPR2) on cumulus cells. cGMP diffuses into oocytes and halts meiosis
Meiosis
Poisonous and flammable gas
resulting in several different cellular effects, including the inhibition of cGMP phosphodiesterases, as well as the formation of nitroxyl and thionitrous
Hydrogen_sulfide
Physiological molecule and therapeutic drug
"Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP". J. Biol. Chem. 282 (29): 20999–21004. doi:10.1074/jbc.M700915200. PMID 17540771
Hyaluronic_acid
Semitic-speaking ethnic group in Ethiopia
but not Oromo, had higher NO3- and cGMP compared with their lowland counterparts. NO3- directly correlated with cGMP." There are four major world regions
Amhara_people
Functions of nitric oxide in organisms
cyclic-guanosine 3',5'-monophosphate (cGMP). The elevation of intracellular cGMP results in relaxation by the activation of cGMP-dependent protein kinase, which
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Oxygen-delivering blood cell and the most common type of blood cell
xenobiotics. Excessive eryptosis is observed in red blood cells lacking the cGMP-dependent protein kinase type I or the AMP-activated protein kinase AMPK
Red_blood_cell
Pharmaceutical company based in the United Arab Emirates
facility was the first in King Abdullah Economic City to be awarded full cGMP certification on its first inspection by the Saudi Food and Drug Authority
Julphar
Biological molecules constituting nucleic acids
nucleotides participate in cell signaling (cyclic guanosine monophosphate or cGMP and cyclic adenosine monophosphate or cAMP) and are incorporated into important
Nucleotide
SNRI medication
approvable from the manufacturing and control standpoint" because of "significant cGMP (current Good Manufacturing Practice) violations at the finished product
Duloxetine
Polyatomic ion (NO3, charge –1) found in explosives and fertilisers
non-selective PDE inhibitors (e.g., caffeine) PDE9 inhibitors (e.g., paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins
Nitrate
Flow control device
The valves used in these industries are usually manufactured according to cGMP guidelines (current good manufacturing practice). Butterfly valves generally
Butterfly_valve
impression (including subscales such as CGI-BP, CGI-C, CGI-E, CGI-I, CGI-S) cGMP cyclic guanosine monophosphate CGN chronic glomerulonephritis CH congenital
List of medical abbreviations: C
List_of_medical_abbreviations:_C
Canadian biopharmaceutical industry and biotechnology company
& process development, analytical development and testing, scale up and cGMP manufacturing, and aseptic fill/finish and lyophilization. As of 2010[update]
Therapure_BioPharma_Inc
Fluid accumulation in the tissue and air spaces of the lungs
Sildenafil's mechanism of action is via phosphodiesterase inhibition which raises cGMP, resulting in pulmonary arterial vasodilation and inhibition of smooth muscle
Pulmonary_edema
Chemical compound
receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral
Spermidine
Involuntary non-striated muscle
membrane bound adenylate cyclase, respectively. The cyclic nucleotides (cGMP and cAMP) produced by these cyclases activate Protein Kinase G and Protein
Smooth_muscle
Atrial natriuretic peptide (or atriopeptin) ANP Peptide heart ANP receptor → cGMP increase sodium and GFR excretion, antagonize venal constriction, inhibit
List_of_human_hormones
Light-sensitive receptor protein
cGMP phosphodiesterase. The cGMP phosphodiesterase hydrolyzes (breaks down) cGMP, lowering its local concentration so it can no longer activate cGMP-dependent
Rhodopsin
Class of enzymes
cyclase, which induces smooth muscle relaxation by: Increased intracellular cGMP, which inhibits calcium entry into the cell, and decreases intracellular
Nitric_oxide_synthase
Class of enzymes
(PDE 4, -7 and -8), others are cGMP selective hydrolases (PDE 5, -6 and -9) and the rest can hydrolyse both cAMP and cGMP (PDE1, -2, -3, -10 and -11). There
Phosphodiesterase_2
Circumstance of death
patients with erectile dysfunction. One treatment for erectile dysfunction is cGMP-specific phosphodiesterase type 5 inhibitors, which enable patients to resume
Death_during_consensual_sex
System of signaling molecules within a cell
proteins. Hydrophilic molecules: water-soluble molecules, such as cAMP, cGMP, IP3, and Ca2+, that are located within the cytosol. Gases: nitric oxide
Second_messenger_system
Type of drugs
in body → release nitric oxide → increase cyclic guanosine monophosphate (cGMP) → vasodilating effects predominant on veins and epicardial coronary vessels
Commonly_prescribed_drugs
Chemical compound
brominated derivative of cyclic guanosine monophosphate (cGMP). It acts as an activator of cGMP-dependent protein kinases. 8-Bromoadenosine 3′,5′-cyclic
8-Bromoguanosine 3',5'-cyclic monophosphate
8-Bromoguanosine_3',5'-cyclic_monophosphate
Class of enzymes
by PDE3 isoforms is also directly inhibited by cGMP, although PDE3B is only ≈10% as sensitive to cGMP inhibition as PDE3A. The PDE3B has been extensively
Phosphodiesterase_3
Chemical compound
non-selective PDE inhibitors (e.g., caffeine) PDE9 inhibitors (e.g., paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins
Amyl_nitrite
Pharmaceutical company
the Patheon brand include small molecule API, biologics, viral vectors, cGMP plasmids, formulation, clinical trials, logistics and commercial manufacturing
Patheon
Protein-coding gene in the species Homo sapiens
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene. GRCh38: Ensembl release 89:
PDE6C
American Physician-Scientist
phosphodiesterase type 5A(PDE5A), which degraded Cyclic guanosine monophosphate(cGMP) and was inhibited by the drug sildenafil (Viagra®), blunted heart contractility
David_Kass_(physician)
Protein family
receptor is activated by the ligation, it can cyclize the guanylate into cGMP. An example of Guanylate cyclase-coupled receptors is ANF receptors (NPR1
Guanylate cyclase-coupled receptor
Guanylate_cyclase-coupled_receptor
monophosphate (cGMP) plays an important role in visual transductions. This fact was well rooted when Fesenko demonstrated that this nucleotide cGMP was able
Transduction_(psychology)
Protein-coding gene in the species Homo sapiens
between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10
MRVI1
Gelatinous substance within the umbilical cord
The email stated that the products are "manufactured in an FDA-registered, cGMP compliant, ISO certified lab", but did not mention that such birth products
Wharton's_jelly
Chemical compounds
protein kinase (EC 2.7.11.11) Protein kinase A PRKACG PRKACB PRKACA PRKY cGMP-dependent protein kinase (EC 2.7.11.12) Protein kinase G PRKG1 Protein kinase
C-Jun_N-terminal_kinases
Improvements in an organization to eliminate non-conformities or undesirable situations
gov. 16 May 2022. Archived from the original on May 13, 2022. Retrieved 2023-03-09. Quality Systems Approach to Pharmaceutical CGMP Regulations (FDA)
Corrective and preventive action
Corrective_and_preventive_action
Toxin harmful to nervous tissue
induce swelling of astrocytes in the brain through increased production of cGMP (Cyclic Guanosine Monophosphate) within the cells which leads to Protein
Neurotoxin
Class of enzymes
catalyze the hydrolysis of cAMP or cGMP to their 5′ monophosphate form. Both enzymes also bind cGMP with high affinity. The cGMP-binding sites are located in
Cyclic nucleotide phosphodiesterase
Cyclic_nucleotide_phosphodiesterase
Chemical compound
in vitro. Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann, RG (2013). "CGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis
Trequinsin
P38 mitogen-activated protein kinases
protein kinase (EC 2.7.11.11) Protein kinase A PRKACG PRKACB PRKACA PRKY cGMP-dependent protein kinase (EC 2.7.11.12) Protein kinase G PRKG1 Protein kinase
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Cyclic nucleic acid
cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic' portion consists of two bonds between the phosphate
Cyclic_nucleotide
German physician and biomedical scientist
(AKAPs), which define cellular PKA responses. Efforts to elucidate cAMP/cGMP mechanisms in cardiovascular cells were then directed to identify selective
Ulrich Walter (clinical biochemist)
Ulrich_Walter_(clinical_biochemist)
Chemical compound
Achim (August 2023). "The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report". Naunyn-Schmiedeberg's
Mosliciguat
Hormone used in regulating the cardiovascular system
Receptor-C (NPR-C). NPR-A and NPR-B use cyclic guanosine monophosphate (cGMP) as its intracellular messenger. NPR-A binds selectively to ANP and BNP while
Natriuretic_peptide
Study and use of medicinal properties of plants
and Drug Administration (FDA) under current good manufacturing practice (cGMP) policy for dietary supplements. Manufacturers of products falling into this
Herbal_medicine
Protein molecule receiving signals for a cell
Receptor Ligand Ion current cyclic nucleotide-gated ion channels cGMP (vision), cAMP and cGTP (olfaction) Na+, K+ IP3 receptor IP3 Ca2+ Intracellular ATP
Receptor_(biochemistry)
Chemical compound
but weaker than theophylline. Paraxanthine is a selective inhibitor of cGMP-preferring phosphodiesterase (PDE9) activity and is hypothesized to increase
Paraxanthine
bisphosphatase (EC 3.1.3.11) Category:EC 3.1.4 Phospholipase C (EC 3.1.4.3) CGMP specific phosphodiesterase type 5 (EC 3.1.4.17) Phospholipase D (EC 3.1.4
List_of_enzymes
Anticoagulant drug
cAMP levels and blocking the platelet aggregation, response to ADP) and/or cGMP. Dipyridamole inhibits the cellular reuptake of adenosine into platelets
Dipyridamole
Class of enzymes
protein kinase (EC 2.7.11.11) Protein kinase A PRKACG PRKACB PRKACA PRKY cGMP-dependent protein kinase (EC 2.7.11.12) Protein kinase G PRKG1 Protein kinase
Cyclin-dependent_kinase
Chemical compound
inhibits phosphodiesterase-5, preventing the degradation of cGMP. The increased levels of cGMP causes vasodilation, resulting in an increased blood flow
Avanafil
CGMP
CGMP
CGMP
CGMP
CGMP
CGMP
CGMP
CGMP
CGMP