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Fourth-generation Cephalosporin Antibiotic
Cefepime is a fourth-generation cephalosporin antibiotic. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria
Cefepime
Combination antibiotics
Cefepime/zidebactam, sold under the brand name Zaynich, is a fixed-dose combination used for the treatment of complicated urinary tract infections. It
Cefepime/zidebactam
Medication
Cefepime/enmetazobactam, sold under the brand name Exblifep, is a medication used for the treatment of urinary tract infections. It is a fixed dose combination
Cefepime/enmetazobactam
Combination antibiotics
Cefepime/sulbactam is a 1:1 fixed-dose combination of cefepime (a fourth-generation cephalosporin) and sulbactam (a β-lactamase inhibitor). The combination
Cefepime/sulbactam
2018 - cefepime/sulbactam 2019 – imipenem/cilastatin/relebactam 2019 – lefamulin 2019 – cefiderocol 2023 – sulbactam/durlobactam 2024 – cefepime/enmetazobactam
Timeline_of_antibiotics
siderophore cephalosporins. Ceftazidime (3rd generation) Cefepime (4th generation) Cefepime/sulbactam Ceftobiprole (5th generation) Ceftolozane/tazobactam
List_of_antibiotics
Species of bacterium
producer and treatment with cefepime is recommended by IDSA if causing disease rather than merely colonising. Treatment using cefepime and gentamicin has been
Enterobacter_cloacae
Pharmaceutical compound
acquired antibiotic resistance worldwide. Taniborbactam, in combination with cefepime, is in clinical trials for the treatment of bacterial infections, including
Taniborbactam
Dangerously low blood pressure due to damage from an organ infection
hospital-acquired pneumonia, a fluoroquinolone can be given, or zoysn, or cefepime, or carbapenem. If the patient has a beta lactam allergy one can give aztreonam
Septic_shock
Irish pharmaceutical company
TYSABRI (natalizumab) AZACTAM (aztreonam for injection, USP) MAXIPIME (cefepime hydrochloride) for Injection Revenue $0.2 million USD (2012) Operating
Élan
enhanced activity against Gram-positive bacteria and Pseudomonas aeruginosa) Cefepime Cefpirome (activity against MRSA and variably VRE. *Not universally accepted
List_of_β-lactam_antibiotics
Combination antibiotic medication
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Aztreonam/avibactam
Class of pharmaceutical drugs
new, related class called oxacephems. Drugs included in this group are cefepime and cefpirome. Some state that cephalosporins can be divided into five
Cephalosporin
Class of enzymes
other oxyimino-beta-lactam substrates (e.g., ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition
Beta-lactamase
Pharmaceutical compound
beta-lactamase inhibitor, preventing the breakdown of other antibiotic drugs. Cefepime Diazabicyclooctane β-lactamase inhibitor Karvouniaris M, Almyroudi MP,
Zidebactam
Chemical compound
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Avibactam
Cefsulodin‡ Cefteram‡ Ceftiolene‡ Oxacephem (Flomoxef Latamoxef‡) 4th generation Cefepime Cefozopran‡ Cefpirome Cefquinome‡ 5th generation Ceftaroline fosamil Ceftolozane
Side_effects_of_penicillin
Pharmaceutical compound
approved for use in the combination cefepime/enmetazobactam (Exblifep). Lanier C, Melton T, Covert K (September 2024). "Cefepime-Enmetazobactam: A Drug Review
Enmetazobactam
Antibiotic
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Benzathine_benzylpenicillin
Iranian pharmaceutical company
Amoxicillin Azithromycin Buspirone Carbamazepine Cefalexin Cefazolin Cefepime Cefixime Ceftazidime Ceftriaxone Cefuroxime Cefalexin Diazepam Erythromycin
Loghman_Pharmaceuticals
Result of nuclear radiation exposure
fourth-generation cephalosporin with pseudomonal coverage: for instance, cefepime, ceftazidime, or an aminoglycoside: for instance, gentamicin, amikacin)
Acute_radiation_syndrome
third-generation cephalosporin) or cefepime (a fourth-generation cephalosporin) +/- amoxicillin or vancomycin. Cefepime exhibits an extended spectrum of
Treatment of infections after exposure to ionizing radiation
Treatment_of_infections_after_exposure_to_ionizing_radiation
Chemical compound
trials in combination with other β-lactam antibiotics such as meropenem, cefepime, and aztreonam for the treatment of complicated urinary tract infections
Nacubactam
Medical intervention
Antibiotic Stability at 25 °C Diluent Existing data in elastomeric pumps cefepime 24 hours normal saline Yes ceftazidime 48 hours normal saline Yes clindamycin
Outpatient parenteral antibiotic therapy
Outpatient_parenteral_antibiotic_therapy
Pharmaceutical drug classification
Cefovecin QJ01DD99 Ceftiofur, combinations J01DE01 Cefepime J01DE02 Cefpirome J01DE03 Cefozopran J01DE51 Cefepime and beta-lactamase inhibitor QJ01DE90 Cefquinome
ATC_code_J01
Species of bacterium
(ciprofloxacin, levofloxacin, but not moxifloxacin) cephalosporins (ceftazidime, cefepime, cefoperazone, cefpirome, ceftobiprole, but not cefuroxime, cefotaxime
Pseudomonas_aeruginosa
Species of bacterium
shows that there is potential for resistance evolution in relation to cefepime for both CMY-2 and TEM-1. The resistance that is gained by CMY-2 and TEM-1
Citrobacter_freundii
Infection that affects part of the urinary tract
about the future of treating those with complicated and recurrent UTI. Cefepime/zidebactam (Zaynich) was approved for medical use in the United States
Urinary_tract_infection
Complication of adulterated cocaine use
marijuana every evening to "come down". He was hospitalized and treated with cefepime, doxycycline, and fluconazole empirically. The next day erythematous painful
Levamisole-induced necrosis syndrome
Levamisole-induced_necrosis_syndrome
Genus of bacteria
species that exhibit especially antibiotic resistant characteristics. Cefepime, a fourth-generation cephalosporin from the β-Lactam antibiotic class.[more
Enterobacter
Species of bacterium
prepared). Traditionally, infections by S. marcescens have been treated with cefepime, carbapenems (Siedner et al., 2014; Tamma et al., 2022 as cited in Tavares-Carreon
Serratia_marcescens
Combination antibiotic drug
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Ampicillin/sulbactam
Chemical compound
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Epicillin
Pneumonia contracted by a hospital patient
and intensive care patients, in whom these bacteria were commonly found. cefepime, ceftazidime, imipenem, meropenem or piperacillin–tazobactam; plus ciprofloxacin
Hospital-acquired_pneumonia
Drugs that inhibit β-Lactamase enzymes
types of non β-lactam cores: Taniborbactam, used in combination with cefepime (cefepime/taniborbactam). Has a boronic acid core. Vaborbactam, used in combination
Β-Lactamase_inhibitor
Antibiotic
baumannii) who had been treated in Germany. Its structure is similar to cefepime and ceftazidime, but a chlorocatechol group at the end of the C-3 side
Cefiderocol
Species of bacterium
"Septicemia in Neutropenic Patients with Clostridium tertium Resistant to Cefepime and Other Expanded-Spectrum Chephalosporins". Journal of Clinical Microbiology
Clostridium_tertium
Chemical compound
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Cefozopran
American biochemist
single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. Antimicrob. Agents Chemother. 54: 4092–4097
Karen_Bush
Infection caused due to gastrointestinal contents entering the lungs
ampicillin/sulbactam, and moxifloxacin. Treatment with piperacillin/tazobactam, cefepime, levofloxacin, imipenem, or meropenem is recommended in cases of potential
Aspiration_pneumonia
Medical condition
Pseudomonas aeruginosa (e.g. cefepime), or carbapenems (imipenem or meropenem). A subsequent meta-analysis published in 2006 found cefepime to be associated with
Febrile_neutropenia
Class of prescription drugs in India
CEFADROXYL 90. CEFATOXIME SODIUM 91. CEFAZOLIN SODIUM 92. CEFDINIR 93. CEFEPIME HYDROCHLORIDE 94. CEFETAMET PIVOXIL 95. CEFPIROME 96. CEFPODOXIME POXETIL
Schedule_H
Chemical compound
Benzathine benzylpenicillin/procaine benzylpenicillin Cefepime/enmetazobactam Cefepime/sulbactam Cefepime/zidebactam Cefoperazone/sulbactam Ceftazidime/avibactam
Carumonam
Species of bacterium
Ampicillin + sulbactam 20 R Augmentin 30 R Apromycin 20 R Carbenicillin 20 R Cefepime 30 R Ceftazidime 10 R Ceftibuten 30 R Cefoxitin 30 R Ceftriaxone 30 R Cefuroxime
Streptomyces_sp._myrophorea
(INN) cefdinir (INN) cefditoren (INN) cefedrolor (INN) cefempidone (INN) cefepime (INN) cefetamet (INN) cefetecol (INN) cefetrizole (INN) cefivitril (INN)
List_of_drugs:_Cb–Ce
Antibiotic medication
"Pharmacodynamics of intermittent and continuous infusion piperacillin/tazobactam and cefepime against extended-spectrum beta-lactamase-producing organisms". International
Piperacillin
Medical condition
bacterium. One regimen is an intravenous antipseudomonal beta-lactam such as cefepime, imipenem, meropenem or piperacillin/tazobactam, plus an IV antipseudomonal
Community-acquired_pneumonia
CCI-779 – CD34 antigen – CD40-ligand – CEA – CEA assay – cecum – cefalexin – cefepime – cefixime – ceftriaxone – celecoxib – celiac disease – cell – cell differentiation
Index_of_oncology_articles
Severe skin reaction to medication
Antibiotics: Penicillin, ampicillin, amoxicillin, clindamycin, cephalexin, cefepime, cefoxitin, cefazolin, various sulfonamides, various quinolones, vancomycin
Acute generalized exanthematous pustulosis
Acute_generalized_exanthematous_pustulosis
Medical condition
expanded-spectrum cephalosporin (e.g., cefotaxime [where available], ceftazidime, or cefepime) plus metronidazole Monotherapy with piperacillin-tazobactam Monotherapy
Clostridial necrotizing enteritis
Clostridial_necrotizing_enteritis
Species of bacterium
therapeutic options, including a broad-spectrum cephalosporin (ceftazidime or cefepime), a combination beta-lactam/beta-lactamase inhibitor (i.e., one that includes
Acinetobacter_baumannii
Antibiotic medication
vancomycin-resistant S. aureus and against Pseudomonas aeruginosa when combined with cefepime, doripenem, imipenem or piperacillin/tazobactam. It also demonstrates potent
Plazomicin
Chemical compound
abafungin, acotiamide, amiphenazole, amthamine, avatrombopag, aztreonam, cefepime, cefixime, ceftizoxime, ceftiofur, ceftibuten, cefpirome, famotidine, meloxicam
2-Aminothiazole
Species of bacterium
imipenem, fluoroquinolones, chloramphenicol, gentamicin, cefoperazone, cefepime, ceftazidime, piperacillin and amikacin. However, some susceptibility
Bordetella_avium
Chemical compound
adjustments of the pH leads to the betaine cefquinome (4). Campylobacter Cefepime Cephalosporin Enterococcus Zwitterion Intervet, "Cephaguard Injection Data
Cefquinome
Bactericidal antibiotics
Examples of 4th generation cephalosporins : A) cefozopran; B) cefclidin; C) cefepime
Discovery and development of cephalosporins
Discovery_and_development_of_cephalosporins
Chemical compound
randomized clinical trial of parenterally administered Cefoselis versus Cefepime for the treatment of acute bacterial infections". European Review. 2014-07-10
Cefoselis
Pneumonia due to use of ventilator
include (but are not limited to): vancomycin/linezolid and ciprofloxacin, cefepime and gentamicin/amikacin/tobramycin vancomycin/linezolid and ceftazidime
Ventilator-associated pneumonia
Ventilator-associated_pneumonia
Infection caused by anaerobic bacteria
bacilli (i.e. aminoglycoside) or an anti-pseudomonal cephalosporin (i.e. cefepime) are generally added to metronidazole, and occasionally cefoxitin when
Anaerobic_infection
Medical condition
ethosuximide and hydantoin (2 cases), and single cases of adalimumab, cefepime, dapsone, doxycycline, griseofulvin, hydantoin, hydralazine, infliximab
Childhood-onset systemic lupus erythematosus
Childhood-onset_systemic_lupus_erythematosus
Medical condition
- nalidixic acid, tetracycline, oxytetracycline, ampicillin-sulbactam, cefepime, fluoroquinolones (M Poh, personal communication, June 1999) Antifungals
Pseudoporphyria
Gentamicin 62.5 Cotrimoxazole 0 Tigecycline 0 Klebsiella spp. 37 Cefotaxime 100 Cefepime 100 Cotrimoxazole 100 Ciprofloxacin 86.4 Gentamicin 83.7 Levofloxacin 72
Health_in_Nepal
Medical intervention
signs, broad spectrum antibiotics should be given (i.e., ceftazidime, cefepime, imipeneum, meropenem, etc.). Abdominal x-ray should also be ordered. If
Management of ulcerative colitis
Management_of_ulcerative_colitis
Indian molecular microbiologist
"Role of the Two Component Signal Transduction System CpxAR in Conferring Cefepime and Chloramphenicol Resistance in Klebsiella pneumoniae NTUH-K2044". PLOS
Govindan_Rajamohan
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