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Chemical compound
acquired Imago BioSciences with the rights to develop bomedemstat in January 2023. Bomedemstat was developed to inhibit the human enzyme lysine-specific
Bomedemstat
(TMT; MCPA), among various others. Other phenylcyclopropylamines include bomedemstat, iadademstat, and vafidemstat. Chemical structures of selected phenylcyclopropylamines
Phenylcyclopropylamine
Experimental enzyme inhibitor
Other LSD1 inhibitors that are under development for medical use include bomedemstat (IMG-7289), iadademstat (ORY-1001), phenelzine (Nardil), pulrodemstat
Vafidemstat
Overproduction of platelets in the bone marrow
clinical trials (NCT04254978) are agents that lower platelets such as bomedemstat. Hydroxycarbamide, interferon-α and anagrelide can lower the platelet
Essential_thrombocythemia
Protein-coding gene in the species Homo sapiens
method is pharmacologic inhibition of LSD1; many such inhibitors such as bomedemstat do not abrogate the scaffold function of LSD1 but rather inhibit the
KDM1A
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