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See searches and references containing BIOCONJUGATION!BIOCONJUGATION
Chemical process
Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. Methods to conjugate
Bioconjugation
Chemical compound
(Japan). Maleimide-mediated methodologies are among the most used in bioconjugation. Due to fast reactions and high selectivity towards cysteine residues
Maleimide
Modular approach to chemical synthesis
and a reporter molecule or other molecular probe, a process called bioconjugation. The possibility of attaching fluorophores and other reporter molecules
Click_chemistry
Chemical compound
reactive with amines and thiols respectively. SMCC is often used in bioconjugation to link proteins with other functional entities (fluorescent dyes, tracers
Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
Succinimidyl_4-(N-maleimidomethyl)cyclohexane-1-carboxylate
Chemical compound
factor 1 secretion. It increases the half-life of acting agents by bioconjugation. The extended half-life is achieved through the addition of a drug affinity
CJC-1295
Chemical compound
chemistry probe that enables highly efficient and completely orthogonal bioconjugation to complex macromolecules including peptides, nucleic acids and proteins
Bicyclononyne
American biochemist
program lies at the intersection of chemistry and biology and develops bioconjugation strategies, cytosolic delivery platforms, and rapid flow synthesis technologies
Bradley_L._Pentelute
DNA or other organic materials. Another surface modification type is bioconjugation. This method uses two biomolecules which are covalently bonded to one
DNA-functionalized quantum dots
DNA-functionalized_quantum_dots
Academic journal
is a monthly peer-reviewed scientific journal covering research in bioconjugation and the interface between man-made and biological materials. The journal
Bioconjugate_Chemistry
Protein conjugation technology
reaction through the SpyTag/SpyCatcher system. Using the Tag/Catcher pair, bioconjugation can be achieved between two recombinant proteins that would otherwise
SpyCatcher
Type of α-amino acid
is a protein-incorporated unnatural amino acid used as a tool for bioconjugation in the field of chemical biology. Phenylalaninol Ihlefeldt, Franziska
Phenylalanine
Chemical compound
Ikada, Y (1995). "Mechanism of Amide Formation by Carbodiimide for Bioconjugation in Aqueous Media". Bioconjugate Chemistry. 6 (1): 123–130. doi:10.1021/bc00031a015
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
American chemist
His research interests include artificial cells, lipid membranes, and bioconjugation. Devaraj attended college at the Massachusetts Institute of Technology
Neal_Devaraj
Method to detect an antigen using an antibody and enzyme
detected by a secondary antibody that is linked to an enzyme through bioconjugation. Between each step, the plate is typically washed with a mild detergent
ELISA
DNA oligonucleotides that can perform a specific chemical reaction
Keijzer JF, Dros M, Zuilhof H, Albada B (2021-09-08). "Aptamer-Assisted Bioconjugation of Tyrosine Derivatives with hemin/G-quadruplex (hGQ) DNAzyme Nucleoapzyme
Deoxyribozyme
Various meanings of the terms
Royzen, Maksim; Fox, Joseph M. (2008). "The Tetrazine Ligation: Fast Bioconjugation based on Inverse-electron-demand Diels-Alder Reactivity". Journal of
Orthogonality
related to delivery and internalisation of ON therapeutics. By exploiting bioconjugation methodology several conjugates have been obtained. The first AOC was
Antibody–oligonucleotide conjugate
Antibody–oligonucleotide_conjugate
Physiological molecule and therapeutic drug
groups. These improvements to HA are achieved through cross-linking and bioconjugation with various molecules, such as acid derivatives, ketones, aldehydes
Hyaluronic_acid
Chemical compound
Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation". Chemical Reviews. 116 (4): 2170–2243. doi:10.1021/acs.chemrev.5b00441
1,2-Epoxybutane
Class of chemical reactions
cycloaddition has been an extremely fast and effective click reaction for bioconjugation, but it is not suitable for use in live cells due to the toxicity of
Bioorthogonal_chemistry
Class of organic compounds
oxidative phosphorylation in molecular biology. Hydrazones are the basis of bioconjugation strategies. Hydrazone-based coupling methods are used in medical biotechnology
Hydrazone
Chemical reaction
Staudinger ligation, which has been called one of the most important bioconjugation methods. Two versions of the Staudinger ligation have been developed
Staudinger_reaction
Scientific discipline
PMID 30645048. Hermanson GT (January 2013). "Chapter 3 - The Reactions of Bioconjugation". In Hermanson GT (ed.). Bioconjugate Techniques (Third ed.). Boston:
Chemical_biology
Suspension of gold nanoparticles in a liquid
Parak WJ (March 2010). "Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles". Philosophical Transactions. Series
Colloidal_gold
Chemical compound
Hexafluorophosphate (TCFH), a Powerful Coupling Reagent for Bioconjugation". Bioconjugate Chemistry. 19 (10): 1968–1971. doi:10.1021/bc8002327
TCFH
functional-group-tolerant reactions is more subtle. For example, peptide bioconjugation reactions make use of the native functionality in amino acid side chains
Late-stage_functionalization
Chemical compound
3-Azidocoumarin is an organic compound that is used in the area of bioconjugation. It is a derivative of coumarin, a natural product and precursor for
3-Azidocoumarin
Chemical reaction that joins diazonium (R–N≡N) to an aromatic compound
Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation". Journal of the American Chemical Society. 139 (34): 11670–11673. Bibcode:2017JAChS
Azo_coupling
Any chemical compound having two acyl groups bonded to the same oxygen atom
Bourel-Bonnet, Line (2021). "Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery" (PDF). Bioconjugate Chemistry. 32 (3): 482–496.
Organic_acid_anhydride
applications by linking them with biomolecules through the process of bioconjugation. The protected gold particles' stability and fluorescence makes them
Thiolate-protected gold cluster
Thiolate-protected_gold_cluster
Electrical discharge between two electrodes separated by an insulating dielectric barrier
Containing Catechol/Quinone Groups: An Alternative to Polydopamine Bioconjugation for Biomedical Applications". Advanced Healthcare Materials. 7 (11)
Dielectric_barrier_discharge
Chemical compound
Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation". Chemical Reviews. 116 (4): 2170–2243. doi:10.1021/acs.chemrev.5b00441
Glycidol
cycloaddition also called the click reaction; which is commonly used in bioconjugation reactions to link molecules together with a stable triazole bridge.
Clicked_peptide_polymer
properties and location of the 21st amino acid, allows for a variety of bioconjugation chemistries to be directed to any specific location within the protein
Allozyne
Class of biopharmaceutical drugs
Yahioglu G (June 2021). "Current strategies for the discovery and bioconjugation of smaller, targetable drug conjugates tailored for solid tumor therapy"
Antibody–drug_conjugate
Chemical compound
inhibitors, neutron capture therapy for cancer, transmembrane transport, and bioconjugation and labeling of proteins and cell surface. 4-Nonylphenylboronic acid
Phenylboronic_acid
Chemical compound
reported to surpass several important drawbacks of existing strategies in bioconjugation, notably the presence of side reactions with other nucleophilic amino
3-Arylpropiolonitriles
Phosphorus-containing ligands
Coupling reaction Organometallic chemistry Ligand Bioconjugation: Transition Metal-Mediated Bioconjugation Reactions Surry, David S.; Buchwald, Stephen L
Dialkylbiaryl phosphine ligands
Dialkylbiaryl_phosphine_ligands
Fluorogenic amine labelling dye
Fluorescamine Wolfbeis, Otto S (2021-08-12). "Fluorescent chameleon labels for bioconjugation and imaging of proteins, nucleic acids, biogenic amines and surface
Pyrylium-1
Croatian chemist
thereof. 2004: BioFuture Award 2017: Publication Award Fluorine Chemistry Bioconjugation Biocontainment Bioorthogonal chemistry Biosafety Biosecurity Biosignature
Nediljko_Budisa
Pericyclic chemical reaction
alkynes (i.e., the Huisgen cycloaddition) has been widely utilized for bioconjugation. The Huisgen reaction generally does not proceed readily under mild
1,3-Dipolar_cycloaddition
laboratories carry out small-molecule synthesis, peptide synthesis, and bioconjugation, including payload–linker development for antibody- drug conjugate (ADC)
BioDuro
American chemistry professor
has developed methods for the total synthesis of proteins and their bioconjugation. Arthur C. Cope Scholar Award (2024) from the American Chemical Society
Philip_E._Dawson
Application of engineering principles to biological molecules
bioconjugation of an enzyme to either an antibody or antigen depending on the type of ELISA. There is much to consider in this enzyme bioconjugation such
Biomolecular_engineering
Protein engineering technology
cases, enzyme conjugates with overall bicyclic topology were generated. Bioconjugation Biotechnology Protein aggregation Protein folding Protein quaternary
In situ cyclization of proteins
In_situ_cyclization_of_proteins
American organic chemist (born 1977)
of Alkyl Carboxylic Acids (2019) Methylation of heteroarenes (2014) Bioconjugation by Native Chemical Tagging of C–H Bonds Direct Synthesis of Fluorinated
Phil_S._Baran
American biomedical engineer
NCAs that are difficult to crystallize. Kramer has also researched bioconjugation reactions of methionine, determining different electrophiles that can
Jessica_Kramer
coupling partner. Typically, hydrazides and aminooxy probes are used in bioconjugation by forming stabilized addition products with carbonyl groups that are
Aldehyde_tag
American chemist
Buchwald and Bradley L. Pentelute on peptide stapling and organometallic bioconjugation chemistry. Spokoyny group's research encompasses an interdisciplinary
Alexander_M._Spokoyny
exceptional selectivity for new-to-nature reactions. With the development of bioconjugation technology, there are plenty of strategies to covalently bind an artificial
Artificial_metalloenzyme
American chemical engineer (1967–2026)
for regenerative medicine. She made use of biomimetic self-assembly, bioconjugation and biosynthesis. In particular, Kiick worked on polymer-peptide macromolecular
Kristi_Kiick
Type of chemical reaction
that could easily be converted to a useful reactive intermediate for bioconjugation applications, although the reactivity was somewhat slower than DIFO
Copper-free_click_chemistry
Chemical compound
Floris P. J. T. (2007). "Metal-Free Triazole Formation as a Tool for Bioconjugation". ChemBioChem. 8 (13): 1504–8. doi:10.1002/cbic.200700278. hdl:2066/34475
Oxanorbornadiene
Family of viruses
filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold". Frontiers in Microbiology. 6: 755. doi:10.3389/fmicb.2015
Filamentous_bacteriophage
Chemical compound
an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation". Angewandte Chemie International Edition. 58 (1): 200–204. doi:10.1002/anie
Pyonitrin
American chemical biologist and protein engineer
and oxaziridines for efficient, stable, and site-specific antibody bioconjugation". Proceedings of the National Academy of Sciences of the United States
James_A._Wells
Group of viruses
filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold". Frontiers in Microbiology. 6: 755. doi:10.3389/fmicb.2015
Ff_phages
Use of viruses as a source of nanoparticles for biomedical purposes
units that can be modified by either genetic modification or chemical bioconjugation methods. Nanotechnology is the manipulation or self-assembly of individual
Virus_nanotechnology
Technologies for targeted drug delivery
nanoparticles is another important design aspect and is often accomplished by bioconjugation or passive adsorption of molecules onto the nanoparticle surface. By
Nanoparticle_drug_delivery
Enzyme
modification pathways have been proposed including protein bioconjugation and PEGylation. Protein bioconjugation synergizes the properties of the two conjugated
Spirotetronate_cyclase_AbyU
streptavidin was attached to the quantum dots. This allowed for a simple bioconjugation to tag the organisms with the quantum dots, by taking advantage of the
History of wildlife tracking technology
History_of_wildlife_tracking_technology
Canadian Scientist
Methods To Enhance Bioconjugation in Metal-Labeled Polystyrene Particles June 2011 Surface Functionalization Methods To Enhance Bioconjugation in Metal-Labeled
Olga_Ornatsky
American vaccine chemist (born 1953)
[citation needed] There, under the guidance of John Inman, Lees learned bioconjugation, the linking together of biologically relevant molecules to increase
Andrew_Lees_(vaccinologist)
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