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The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable
AP2_adaptor_complex
Links clathrin to receptors in coated vesicles
AP complexes in mammals. AP1 is responsible for the transport of lysosomal hydrolases between the trans-Golgi network, and endosomes. AP2 adaptor complex
Clathrin_adaptor_protein
Protein found in humans
adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two
Adaptor-related protein complex 2, alpha 1
Adaptor-related_protein_complex_2,_alpha_1
Protein complex transporting molecules inside the cell
this figure. AP2 adaptor complex Clathrin vesicles COPII vesicles Paczkowski JE, Richardson BC, Fromme JC (July 2015). "Cargo adaptors: structures illuminate
Exomer
Topics referred to by the same term
acids AP2 adaptors (AP-2 complex), which aid clathrin mediated endocytosis Apetala 2 (AP2), a plant transcription factor Automotive products AP2, Automatic
AP2
Protein-coding gene in the species Homo sapiens
encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The
AP2B1
Protein family
constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex". J. Neurochem. 101 (4): 898–905. doi:10.1111/j.1471-4159.2006.04399
Beta2-adaptin C-terminal domain
Beta2-adaptin_C-terminal_domain
Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location
Vesicular transport adaptor protein
Vesicular_transport_adaptor_protein
Protein-coding gene in humans
hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning. AP2 adaptor complex GRCh38: Ensembl release
AP4S1
Protein-coding gene in the species Homo sapiens
Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene and is involved
AAK1
Protein-coding gene in the species Homo sapiens
108.3.833. PMC 2115374. PMID 2564002. "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei
AP2A2
Protein family
adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit from various clathrin adaptor protein complexes
Adaptor complexes medium subunit domain
Adaptor_complexes_medium_subunit_domain
evolved from part of an ancient cargo adaptor protein complex named TSET. AP2 adaptor complex Vesicular transport adaptor protein Umasankar PK, Ma L, Thieman
Muniscins
Protein-coding gene in the species Homo sapiens
of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is
AP2M1
Index of articles on biophysics
H I J K L M N O P Q R S T U V W X Y Z 5-HT3 receptor ACCN1 ANO1 AP2 adaptor complex Aaron Klug Acid-sensing ion channel Activating function Active transport
Index_of_biophysics_articles
Mammalian protein found in humans
cell surface. Uncleaved PAR1 in the cell membrane gets bound by the AP2 adaptor complex at a tyrosine motif on the intracellular C-terminus, which stimulates
Proteinase-activated receptor 1
Proteinase-activated_receptor_1
polymerised clathrin with adaptor complexes bound to the membrane. Schmid EM, Ford MG, Burtey A, et al. (September 2006). "Role of the AP2 beta-appendage hub
Matricity
Protein-coding gene in the species Homo sapiens
AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. One of two major clathrin-associated adaptor complexes, AP-2, is a
AP2S1
Protein-coding gene in the species Homo sapiens
interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other
EPN1
Family of proteins
to elements of the internalization machinery, clathrin and clathrin adaptor AP2, which promotes receptor internalization via coated pits and subsequent
Arrestin
Protein-coding gene in the species Homo sapiens
AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene. This gene encodes a subunit of the heterotetrameric adaptor-related
AP1M2
Protein-coding gene in the species Homo sapiens
Lundmark R; Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting
SNX9
Protein-coding gene in the species Homo sapiens
regulates sorting signal recognition by the clathrin-associated adaptor complex AP2" (PDF). Mol. Cell. 18 (5): 519–31. doi:10.1016/j.molcel.2005.04.019
TGOLN2
Protein-coding gene in the species Homo sapiens
Paing MM, Johnston CA, Siderovski DP, Trejo J (April 2006). "Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial
GTF3A
Cellular process
and are not representative of the membrane as a whole. AP2 adaptors are multisubunit complexes that perform this function at the plasma membrane. The
Endocytosis
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
to β2-adrenoreceptors acts as an adaptor for binding with clathrin, and with the beta-subunit of AP2 (clathrin adaptor molecules); thus, the arrestin here
G_protein-coupled_receptor
Protein-coding gene in the species Homo sapiens
identifiable clathrin- or AP2-binding sequences, and therefore cannot form stable intramolecular contacts with clathrin and AP2, which has been observed
VPS26A
Protein-coding gene in the species Homo sapiens
(November 1995). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics
Valosin-containing_protein
Protein that regulates the rate of DNA transcription
Class: E1A-like factors 0.5 Class: AP2/EREBP-related factors 0.5.1 Family: AP2 0.5.2 Family: EREBP 0.5.3 Superfamily: AP2/B3 0.5.3.1 Family: ARF 0.5.3.2 Family:
Transcription_factor
Protein-coding gene in the species Homo sapiens
human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families". J. Biol. Chem. 277 (44):
Loricrin
Protein-coding gene in the species Homo sapiens
Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis". J. Biol. Chem. 281 (29): 20632–42. doi:10.1074/jbc
PIP5K1C
Protein found in humans
the product of this gene in neuronal synapses in conjunction with protein AP2 has been seen in increased amounts in the hippocampal neurons of Alzheimer's
ADAM10
Personal computer sold in Britain
production of the unit had ceased in November 1985. The Advanced Plus 2 (AP2) ROM was later sold by PRES as a replacement ROM for the Plus 1, of whose
Acorn_Electron
Protein-coding gene in the species Homo sapiens
G proteins while also linking DP2 to elements, clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2
Prostaglandin_DP2_receptor
high avidity interactions by multiple low affinity motifs (e.g. multiple AP2-binding motifs in Eps15). SLiM functions in almost every pathway due to their
Short_linear_motif
et al. (2002). "HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light
HIP1R
Study of RNA transcripts
salinity stresses, including identifying the role of transcript isoforms of AP2-EREBP. Investigation of gene expression during biofilm formation by the fungal
Transcriptomics_technologies
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