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Chemical compound
2006). "Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist
A-349821
Antihistamine medication
Cetirizine is a second-generation peripherally selective antihistamine used to treat allergic rhinitis (hay fever), dermatitis, urticaria (hives), and
Cetirizine
Antihistamine drug
used either by mouth or injection into a muscle. Hydroxyzine works by blocking the effects of histamine. It is a first-generation antihistamine in the
Hydroxyzine
Atypical antipsychotic medication
Quetiapine (/kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment
Quetiapine
Atypical antipsychotic medication
Aripiprazole, sold under the brand name Abilify, among others, is a unique atypical antipsychotic primarily used in the treatment of schizophrenia, mania
Aripiprazole
Antihistamine medication
than sedation. It is a first-generation H1-antihistamine (i.e. it blocks histamine) with sedative effects. Diphenhydramine is also a potent anticholinergic
Diphenhydramine
Antidepressant medication
to treat major depressive disorder, anxiety disorders, and insomnia. It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor
Trazodone
Antihistamine medication
itchy inflamed eyes (allergic conjunctivitis) caused by an allergy. It is a second-generation antihistamine and takes effect by selectively inhibiting
Bilastine
Drug that blocks histamine or histamine agonists
Hancock AA (September 2004). "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical
Antihistamine
Antihistamine medication
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. This includes allergic rhinitis (hay fever) and
Loratadine
Medication for nausea, psychosis, and anxiety
name Compazine among others, is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety. It is a less preferred medication for
Prochlorperazine
Antihistamine medication
rhinitis and urticaria. It is a common over-the-counter medication available under many brand names (including Allegra), as well as a generic drug. Therapeutically
Fexofenadine
Medication that reduces stomach acid
Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production. It
Famotidine
Antidepressant medication
Withdrawal symptoms may occur when stopping. It is not recommended together with a monoamine oxidase inhibitor, although evidence supporting the danger of this
Mirtazapine
Anti-emetic and antihistamine medication
nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine and 8-chlorotheophylline (a theophylline relative) in a 1:1 ratio. Dimenhydrinate
Dimenhydrinate
Muscle relaxant medication
Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden
Cyclobenzaprine
Chemical compound
chain in histidine has a pKa of approximately 6.0. Thus, below a pH of 6, the imidazole ring is mostly protonated and carries a positive +1 charge (as
Histidine
Antihistamine medication
Levocetirizine, sold under the brand name Xyzal, among others, is a second-generation antihistamine used for the treatment of allergic rhinitis (hay fever)
Levocetirizine
Atypical antipsychotic medication
disease and long-term maintenance. It is taken by mouth or by injection into a muscle. Common side effects include feeling tired, dizziness, constipation
Olanzapine
First-generation antihistamine used as a short-term sedative and hypnotic (sleep aid)
histamine H1 receptor. As a first-generation antihistamine, it typically crosses the blood–brain barrier into the brain, thereby producing a suite of sedative
Doxylamine
Allergy medication
Desloratadine, sold under the brand name Aerius among others, is a tricyclic H1 receptor inverse agonist that is used to treat allergies. It is the major
Desloratadine
Tricyclic antidepressant
brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as
Amitriptyline
Chemical compound
is taken by mouth. Effects generally begin in an hour and last for up to a day. Common side effects include sleepiness and dry mouth. Serious side effects
Meclizine
Skeletal muscle relaxant
ethanolamine antihistamine class; it is closely related to diphenhydramine. It is a muscle relaxant that is used to treat muscle pain and to help with motor control
Orphenadrine
Antihistamine used to treat allergies
medication takes effect within two hours and lasts for about 4–6 hours. It is a first-generation antihistamine and works by blocking the histamine H1 receptor
Chlorphenamine
Medication to treat narcolepsy
Pitolisant, sold under the brand name Wakix among others, is a medication used for the treatment of excessive daytime sleepiness in adults with narcolepsy
Pitolisant
Sedating antihistamine
Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies
Promethazine
Antipsychotic medication
Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as
Perphenazine
Chemical compound
efficacy. Studies of the use of betahistine have shown a reduction in symptoms of vertigo and, to a lesser extent, tinnitus, but conclusive evidence is lacking
Betahistine
Organic compound involved in immune responses
acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator
Histamine
Medication that decreases stomach acid
Ranitidine, sold under the brand name Zantac among others, is a medication used to decrease stomach acid production. It is used in the treatment of peptic
Ranitidine
Antidepressant
Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression. It is also
Imipramine
Chemical compound
sold under the brand name Astelin among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever)
Azelastine
Atypical antipsychotic medicine
2020. Retrieved 20 October 2020. Laszlovszky I, Barabássy Á, Németh G (July 2021). "Cariprazine, A Broad-Spectrum Antipsychotic for the Treatment of Schizophrenia:
Cariprazine
Typical antipsychotic medication
Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication of the phenothiazine class. It is used
Fluphenazine
Antipsychotic medication
of suicide, and high blood sugar levels. In older people with psychosis as a result of dementia, it may increase the risk of death. It is unknown if it
Risperidone
Antihistamine and calcium channel blocker medication
of only a few drugs that has a beneficial effect in the chronic treatment of the vertigo and tinnitus associated with Ménière's disease. In a clinical
Cinnarizine
Sedating antidepressant
For hives it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness
Doxepin
Chemical compound
Tripelennamine, sold under the brand name Pyribenzamine by Novartis, is a drug that is used as an antipruritic and first-generation antihistamine. It
Tripelennamine
Antipsychotic medication
schizophrenia and bipolar disorder. It may be used by mouth and by injection into a muscle (IM). The intramuscular form may be used for acute agitation in people
Ziprasidone
Antidepressant medication
Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain
Nortriptyline
Second generation H1-antihistamine
Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by
Rupatadine
Medication for movement disorders
Nonproprietary Name), known as benztropine in the United States and Japan, is a medication used to treat movement disorders like parkinsonism and dystonia
Benzatropine
Class of receptor proteins that bind histamine
histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand. Histamine is a neurotransmitter involved
Histamine_receptor
Class of medications
antagonists, sometimes referred to as H2RAs and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2
H2_receptor_antagonist
Allergy medication
Clemastine, also known as meclastin, is a first-generation H1 histamine antagonist (antihistamine) with anticholinergic properties (drying) and sedative
Clemastine
Class of medications
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were
Tricyclic_antidepressant
Typical antipsychotic medication
mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein). Chlorpromazine is in the typical antipsychotic
Chlorpromazine
Chemical compound
Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease
Nizatidine
Antihistamine drug
Ebastine is a H1 antihistamine with low potential for causing drowsiness. It does not penetrate the blood–brain barrier to a significant amount and thus
Ebastine
First generation antihistamine
Mepyramine, also known as pyrilamine, is a first-generation antihistamine, targeting the H1 receptor as an inverse agonist. Mepyramine rapidly permeates
Mepyramine
Antidopaminergic drug
droperidol is a butyrophenone which acts as a potent D2 (dopamine receptor) antagonist with some histamine and serotonin antagonist activity. It has a central
Droperidol
Tricyclic antidepressant
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). It is used in the treatment of various conditions
Clomipramine
Chemical compound
Chloropyramine is a first-generation antihistamine drug approved in several Eastern European countries such as Russia for the treatment of allergic conjunctivitis
Chloropyramine
Chemical compound
Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. It is
Brompheniramine
Typical antipsychotic drug of the thioxanthene class
(former BAN), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of the thioxanthene class. It was introduced in
Flupentixol
Antipsychotic medication
the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during
Acepromazine
Atypical antipsychotic medication
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. It
Clozapine
Chemical compound
and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine
Pheniramine
Antihistamine medication
name Periactin among others, is a first-generation antihistamine which is used to treat allergies. In addition, it has a number of off-label uses, such
Cyproheptadine
Typical antipsychotic medication
methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency
Levomepromazine
Drug used to treat depressive and anxiety disorders
Europe. Despite chemically being a tricyclic dibenzazepine (iminostilbene) derivative similar to imipramine, opipramol is not a monoamine reuptake inhibitor
Opipramol
Class of pharmaceutical drugs
Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced in the 1970s. They are named after their tetracyclic chemical
Tetracyclic_antidepressant
Heterocyclic compound containing a ring of four carbon, one nitrogen and one sulfur atom
was a pioneering example of medicinal chemistry; phenothiazine is often discussed as a prototypical example of a pharmaceutical lead structure. A number
Phenothiazine
Typical antipsychotic medication
is a medication used to treat schizophrenia and other psychoses. It is classed, pharmacologically, as a typical antipsychotic. Chemically it is a thioxanthene
Zuclopenthixol
Typical antipsychotic medication
Chlorprothixene, sold under the brand name Truxal among others, is a typical antipsychotic of the thioxanthene group. Chlorprothixene's principal indications
Chlorprothixene
Drug used to reduce frequency of headaches
is an antimigraine agent of the tricyclic group which is used primarily as a preventative to reduce the frequency of recurrent migraine headaches. The
Pizotifen
Antihypertensive agent
dry mouth, weight gain, and QT interval prolongation. Ketanserin acts as a selective antagonist of the serotonin 5-HT2A, α1-adrenergic, and histamine
Ketanserin
Antidepressant
known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression
Dosulepin
Pharmaceutical compound
States Adopted Name; developmental code names BEN-2001 and JNJ-31001074) is a histamine H3 receptor receptor antagonist which was under development for
Bavisant
Typical antipsychotic medication
Tiotixene, or thiothixene, is a typical antipsychotic sold under the brand name Navane which is predominantly utilised to treat schizophrenia. Beyond
Tiotixene
Antidepressant
Trimipramine, sold under the brand name Surmontil among others, is a tricyclic antidepressant (TCA) which is used to treat depression. It has also been
Trimipramine
Chemical compound
Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its
Acrivastine
Antihistamine medication
conjunctivitis and allergic rhinitis (hay fever). It is used as eye drops or as a nasal spray. The eye drops generally result in an improvement within half
Olopatadine
Pharmaceutical compound
ALTO-203 is a histamine H3 receptor inverse agonist which is under development for the treatment of major depressive disorder with anhedonia. It was also
ALTO-203
Chemical compound
α-Methylhistamine is a synthetic derivative and a selective histamine H3 receptor agonist. It decreases blood pressure and heart rate in guinea pigs. The
Α-Methylhistamine
Pharmaceutical compound
TS-091) is an experimental drug under investigation as a potential treatment for narcolepsy. It is a member of the histamine H3 receptor antagonist/inverse
Enerisant
Antidepressant
among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression. It may alternatively be classified as a tricyclic antidepressant
Maprotiline
Chemical compound
hay fever. Terfenadine acts as a peripherally-selective antihistamine, or antagonist of the histamine H1 receptor. It is a prodrug, generally completely
Terfenadine
Medication to treat schizophrenia
mianserin. It was initially approved in the United States in 2009 and approved as a generic medication in 2020. Asenapine has been approved by the FDA for the
Asenapine
Experimental drug to treat narcolepsy
name SUVN-G3031) is an experimental wakefulness-promoting agent acting as a selective histamine H3 receptor inverse agonist which is under development
Samelisant
Antihistamine medication
(BP-1-5375) L-Histidine Methimepip Proxyfan SCH-50971 VUF-5297 Antagonists A-349821 A-423579 ABT-239 ABT-652 ALTO-203 AZD5213 Bavisant Betahistine Burimamide
Triprolidine
Chemical compound
Lisuride, sold under the brand name Dopergin among others, is a monoaminergic medication of the ergoline family which is used in the treatment of Parkinson's
Lisuride
Pharmaceutical compound
USANTooltip United States Adopted Name; developmental code name CEP-26401) is a histamine H3 receptor antagonist and inverse agonist which was under development
Irdabisant
Typical antipsychotic medication
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia
Haloperidol
Active metabolite of the drug clozapine
N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses
Desmethylclozapine
Atypical antipsychotic medication
efficacy as an antimanic agent in patients with acute bipolar mania. In a 2013 study in a comparison of 15 antipsychotic drugs in effectivity in treating schizophrenic
Zotepine
Pharmaceutical compound
BP 2.94, or BP-294, also known as FUB-94, is a histamine H3 receptor agonist which was under development for the treatment of asthma, inflammation, pain
BP_2.94
Antidepressant
brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine
Desipramine
Chemical compound
others), is used as a short-term add-on treatment for psychomotor agitation. Its approved uses in people is limited, but is used as a tranquilizer in veterinary
Promazine
Atypical antipsychotic medication
primary uses are in the treatment of schizophrenia and bipolar mania. In a clinical trial that compared it to haloperidol in the treatment of schizophrenia
Perospirone
Drugs that block the action of histamine
H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H1 receptor, helping to relieve allergic
H1_antagonist
Chemical compound
Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination
Antazoline
Chemical compound
A-423,579 is one of a range of histamine antagonists developed by Abbott Laboratories which are selective for the H3 subtype, and have stimulant and anorectic
A-423579
Pharmaceutical compound
SCH-50971 is a histamine H3 receptor agonist which was under development for the treatment of anxiety disorders, gastrointestinal disorders, and migraine
SCH-50971
Chemical compound
Levocabastine (trade name Livostin or Livocab, depending on the region) is a selective second-generation H1 receptor antagonist which was discovered at
Levocabastine
Antidepressant
primarily for treating depression in Europe and other countries[which?]. It is a tetracyclic antidepressant (TeCA) and is closely related to mirtazapine in
Mianserin
Antipsychotic drug
treatment of L-DOPA and other forms of psychosis in Parkinson's disease (although a multicentre, double-blind, placebo-controlled study conducted in 2012 failed
Melperone
Chemical compound
Bepotastine (Talion, Bepreve) is a 2nd generation antihistamine. It was approved in Japan for use in the treatment of allergic rhinitis and urticaria/pruritus
Bepotastine
Calcium channel blocker medication
Flunarizine, sold under the brand name Sibelium among others, is a drug classified as a calcium antagonist which is used for various indications. It is
Flunarizine
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