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6 PHOSPHOGLUCONOLACTONE

• 6-Phosphogluconolactone

Chemical compound

6-Phosphogluconolactone is an intermediate in the pentose phosphate pathway (PPP). In the PPP, it is produced from glucose-6-phosphate by glucose-6-phosphate

6-Phosphogluconolactone



6-Phosphogluconolactone

• Entner–Doudoroff pathway

Series of interconnected biochemical reactions

Cofactors: Mg2+ The G6P is then converted to 6-phosphogluconolactone (6PGL) in the presence of enzyme glucose-6-phosphate dehydrogenase (an oxido-reductase)

Entner–Doudoroff pathway



Entner–Doudoroff_pathway

• 6-phosphogluconolactonase

Cytosolic enzyme

6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

6-phosphogluconolactonase



6-phosphogluconolactonase

• 6-Phosphogluconic acid

Chemical compound

oxidative phase of the pentose phosphate pathway, it is formed from 6-phosphogluconolactone by 6-phosphogluconolactonase, and in turn, it is converted to ribulose

6-Phosphogluconic acid



6-Phosphogluconic_acid

• Glucose-6-phosphate dehydrogenase

Enzyme involved in the production of energy by cells

chemical reaction: Glucose 6-phosphonic acid + NADP+       H+   H+   6-Phosphogluconolactone + NADPH   This enzyme participates in the pentose phosphate pathway

Glucose-6-phosphate dehydrogenase



Glucose-6-phosphate_dehydrogenase

• Glucose-6-phosphate dehydrogenase (coenzyme-F420)

Glucose 6-phosphonic acid + oxidized coenzyme F420               6-Phosphogluconolactone + reduced coenzyme F420   Thus enzyme is specific for D-glucose 6-phosphate

Glucose-6-phosphate dehydrogenase (coenzyme-F420)



Glucose-6-phosphate_dehydrogenase_(coenzyme-F420)

• Committed step

Irreversible reaction step at the branch points of biochemical pathways

fatty acid biosynthesis. Glucose-6-phosphate dehydrogenase catalyzes the conversion of G6P into 6-phosphogluconolactone to produce NADPH in the first and

Committed step



Committed_step

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