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Chemical compound
4-Hydroxycoumarin is a coumarin derivative with a hydroxy group at the 4-position. 4-Hydroxycoumarin is an important fungal metabolite from the precursor
4-Hydroxycoumarin
Group of anticoagulant drugs
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules. Chemically, they are derived from coumarin by adding a hydroxy
4-Hydroxycoumarins
Class of enzymes
4-hydroxycoumarin synthase (EC 2.3.1.208, BIS2, BIS3) is an enzyme with systematic name malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase. This enzyme
4-Hydroxycoumarin_synthase
Chemical compound
Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison. In recent years, it has become one of the world's most widely
Brodifacoum
Species of flowering tree in the pea family
anticoagulant prescription drugs, such as warfarin, are based on 4-hydroxycoumarin, a chemical derivative of coumarin initially isolated from this bean
Dipteryx_odorata
Organic compounds derived from coumarin
considered phenylpropanoids. Among the most important derivatives are the 4-hydroxycoumarins, which exhibit anticoagulant properties, a characteristic not present
Coumarin_derivatives
Chemical compound
is a potent anticoagulant rodenticide. It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin"
Bromadiolone
Anticoagulant medication
which is formed from the 4-hydroxycoumarin and the ketone in the 3-position substituent. However, the existence of many 4-hydroxycoumadin anticoagulants
Warfarin
Aromatic chemical compound
incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins. Some of the 4-hydroxycoumarin anticoagulant class of chemicals are designed to have
Coumarin
Reaction in organic chemistry
A well-known Michael reaction is the synthesis of warfarin from 4-hydroxycoumarin and benzylideneacetone first reported by Link in 1944: Several asymmetric
Michael_addition_reaction
Chemical compound
history. Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was
Dicoumarol
Group of substances
can cause birth defects (teratogens). Coumarins (more accurately 4-hydroxycoumarins) are the most commonly used VKAs. In medicine, the most commonly used
Vitamin_K_antagonist
Index of chemical compounds with the same name
Hydroxycoumarin may refer to: 4-Hydroxycoumarin 7-Hydroxycoumarin (umbelliferone) This set index article lists chemical compounds articles associated
Hydroxycoumarin
Chemical used to kill rodents
addition to this specific metabolic disruption, massive toxic doses of 4-hydroxycoumarin, 4-thiochromenone and 1,3-indandione anticoagulants cause damage to
Rodenticide
Chemical compound
Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide. Coumatetralyl is commonly used with grains
Coumatetralyl
Drug
influence the dose needed to achieve the desired INR. Phenprocoumon, a 4-hydroxycoumarin structurally similar to warfarin, is a white to off-white crystalline
Phenprocoumon
Chemical compound
Difenacoum is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It has anticoagulant effects and is used commercially as a rodenticide
Difenacoum
Chemical compound
Flocoumafen is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency)
Flocoumafen
Fat-soluble vitamers
subset, 4-hydroxycoumarins, act as vitamin K antagonists. They block the regeneration and recycling of vitamin K. Some of the 4-hydroxycoumarin anticoagulant
Vitamin_K
Chemical compound
Tioclomarol is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation drug, used as a rodenticide that is effective
Tioclomarol
Chemical compound (4-hydroxy-6-methyl-2-pyrone)
is used for metal extraction and plating and as a food additive. 4-Hydroxycoumarin - bicyclic analogue "New Sustainable Production Method Could Advance
Triacetic_acid_lactone
Anticoagulant
Hepatic Elimination half-life 8 to 11 hours Identifiers IUPAC name (RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one CAS Number 152-72-7 Y PubChem
Acenocoumarol
Chemical compound
3-azidocoumarin. The isomeric 4-azidocoumarin (CAS# 42373-56-8) product can also be prepared from 4-hydroxycoumarin via the 4-chloro derivative, which reacts
3-Azidocoumarin
American biochemist
and tested it; it turned out to be dicoumarol (3,3'-methylenebis-(4 hydroxycoumarin)). Dicoumarol was subjected to clinical trials at Wisconsin General
Karl_Paul_Link
Species of legume
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta (roxb.) benth"
Derris_robusta
Property of substances to change colour due to a change in temperature
acids include bisphenol A, parabens, 1,2,3-triazole derivates, and 4-hydroxycoumarin and act as proton donors, changing the dye molecule between its leuco
Thermochromism
Chemical compound
benzylideneacetone results in a preparation of benzylacetone. The reaction of 4-Hydroxycoumarin with this compound yields Warfarin. Claisen, L. "Über die Einwirkung
Benzylideneacetone
Medical condition
deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins, such as warfarin). Warfarin necrosis is a rare but severe complication
Warfarin_necrosis
Chemical compound
vitamin K antagonist oral anticoagulant". Thrombosis and Haemostasis. 117 (4): 706–717. doi:10.1160/TH16-08-0623. PMID 28180234. S2CID 4356089. Spreitzer
Tecarfarin
Pharmaceutical drug
B01AA08 (WHO) Identifiers IUPAC name 3,3-(ethyl acetate-methylene)-bis(4-hydroxycoumarin) CAS Number 548-00-5 N PubChem CID 11047 DrugBank DB08794 Y ChemSpider
Ethyl_biscoumacetate
Chemical compound
agent. It belongs to the 4-thiochromenone or benzothiopyranone class of rodenticides, which differs from 4-hydroxycoumarins by the substitution of an
Difethialone
Dutch clinical chemist (1930–2020)
chromatographic method for the estimation of phenprocoumon, 3-(1-phenyl-propyl)-4-hydroxycoumarin (marcoumar®, liquamar®), in human serum or plasma". Clinica Chimica
Paul_Brombacher
Method in organic chemistry
warfarin (in equilibrium with the hemiketal) in a Michael addition of 4-hydroxycoumarin and benzylideneacetone: A recent exploit is the vinyl alkylation of
Organocatalysis
synthase EC 2.3.1.208: 4-hydroxycoumarin synthase EC 2.3.1.209: dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase EC 2.3.1.210: dTDP-4-amino-4,6-dideoxy-D-galactose
List_of_EC_numbers_(EC_2)
Chemical reaction discovered by and named after W. Baker and K. Venkataraman
Baker-Venkataraman rearrangement. Regiospecific route to substituted 4-hydroxycoumarins". Tetrahedron Letters. 39 (28): 4995–4998. doi:10.1016/S0040-4039(98)00977-0
Baker–Venkataraman rearrangement
Baker–Venkataraman_rearrangement
Chemical compound
Umbelliferone, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a natural product of the coumarin family. It absorbs
Umbelliferone
Index of chemical compounds with the same molecular formula
031694 u) may refer to: Umbelliferone, also known as 7-hydroxycoumarin or hydrangine 4-Hydroxycoumarin This set index page lists chemical structure articles
C9H6O3
Chemical compound
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth"
Derrubone
Indian spice derived from Ferula roots
Walia, Karvita (1973). "Effect of Asafoetida (7-Hydroxycoumarin) on Mouse Spermatocytes". Cytologia. 38 (4): 719–724. doi:10.1508/cytologia.38.719. ISSN 0011-4545
Asafoetida
Enzyme
UDP-glucose:o-hydroxycoumarin 7-O-glucosyltransferase from tobacco cell cultures". Plant Sci. Lett. 18 (2): 177–184. doi:10.1016/0304-4211(80)90048-6. Enzyme 2.4.1
O-dihydroxycoumarin 7-O-glucosyltransferase
O-dihydroxycoumarin_7-O-glucosyltransferase
Chemical compound
Like most phenylpropanoids, the biosynthetic precursor to scopoletin acid is 4-coumaroyl-CoA. Scopoletin is derived from 1,2-benzopyrones which is the core
Scopoletin
coumestrol MeSH D03.438.150.446.400 – esculin MeSH D03.438.150.446.520 – 4-hydroxycoumarins MeSH D03.438.150.446.520.079 – acenocoumarol MeSH D03.438.150.446
List_of_MeSH_codes_(D03)
Chemical compound
causing death), which are toxic to humans and some animals. Daphnin is a hydroxycoumarin compound. Coumarins are a family of benzopyrones widely distributed
Daphnin
Class of enzymes
NRF2 inducers with downstream HO-1 induction include: genistein, 3-hydroxycoumarin, oleanolic acid, isoliquiritigenin, PEITC, diallyl trisulfide, oltipraz
Heme_oxygenase
Protein found in humans
coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity. The CYP2A6 gene is part of
CYP2A6
Chemical compound
evolved trait. Iodination of commercially available umbelliferone (7-hydroxycoumarin) yields 7-hydroxy-8-iodocoumarin. Acetoxy group can be introduced into
Angelicin
Chemical compound
Pacific Blue, or systematically 3-carboxy-6,8-difluoro-7-hydroxycoumarin, is a fluorophore used in cell biology. Its excitation maximum lies at 401 nm
Pacific_Blue_(dye)
Chemical compound
Molecular Structure of Daphnin Dihydrate: 7-(β-D-Glucopyranosyloxy)-8-hydroxycoumarin Dihydrate". Bulletin of the Chemical Society of Japan. 56 (6): 1577–1580
Daphnetin
Protein-coding gene in the species Homo sapiens
O'Kennedy R, Bogan DP (August 1996). "Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC". Journal of Pharmaceutical and Biomedical Analysis. 14 (11):
UGT1A6
Agents that emit light after excitation by light
2174/1385272811317060003 Juan Carlos Stockert, Alfonso Blázquez-Castro (2017). "Chapter 4 Fluorescent Labels". Fluorescence Microscopy in Life Sciences. Bentham Science
Fluorophore
American biotechnology company
scientists at Aurora invented CCF2, a dye combining fluorescein and 7-hydroxycoumarin that creates a fluorescent signal when cleaved by beta-lactamase; this
Aurora_Biosciences
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